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Current position:Product Center > Antibodies > Biosimilar Antibodies > Anti-BTLA hIgG4 Antibody(22B3)
Anti-BTLA hIgG4 Antibody(22B3)
Product info

Cat.No:GM-50103AB

Product:Anti-BTLA hIgG4 Antibody(22B3)




Cat. No. & Size

GM-50103AB-10           10 μg

GM-50103AB-100         100 μg

GM-50103AB-1000       1mg

Description️

Species Reactivity      Human

Clone                           22B3

Source/Isotype           Monoclonal human IgG4, κ

Application                 Flow Cytometry; Block assay 

Specificity                   Detects BTLA

Gene                            BTLA

Other Names              BTLA1, CD272

Gene ID                       151888

Background                B- and T-lymphocyte attenuator or BTLA (also known as cluster of differentiation 272 or CD272) is a protein that belongs to the CD28 immunoglobulin superfamily (IgSF) which is encoded by the BTLA gene located on the 3rd human chromosome. BTLA is a 289 amino acid long transmembrane glycoprotein. It consists of an extracellular domain, a transmembrane domain, and a cytoplasmic domain, similar in structure to PD-1 and CTLA-4. HVEM is the main ligand of BTLA which has inhibition and activation capacities. When a T cell is fully activated HVEM is internalized, and this allows BTLA to interact in a trans manner (with molecules on other cells). This enables other cells who express HVEM to regulate activated T cells. Treg cells express HVEM and can facilitate immune suppression through interaction with BTLA. Furthermore, the blockage of BTLA together with PD-1 can help reverting the state of exhaustion.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay

Data

/ueditor/image/20240514/1715675638136578/8a4e2d516de4c2cfaae3d00ab31b44fd.png


GM-50103AB-2.png

Current position:Product Center > -- > Anti-BTLA hIgG4 Antibody(22B3)
classify
Anti-BTLA hIgG4 Antibody(22B3)
Product info

Cat.No:GM-50103AB

Product:Anti-BTLA hIgG4 Antibody(22B3)




Cat. No. & Size

GM-50103AB-10           10 μg

GM-50103AB-100         100 μg

GM-50103AB-1000       1mg

Description️

Species Reactivity      Human

Clone                           22B3

Source/Isotype           Monoclonal human IgG4, κ

Application                 Flow Cytometry; Block assay 

Specificity                   Detects BTLA

Gene                            BTLA

Other Names              BTLA1, CD272

Gene ID                       151888

Background                B- and T-lymphocyte attenuator or BTLA (also known as cluster of differentiation 272 or CD272) is a protein that belongs to the CD28 immunoglobulin superfamily (IgSF) which is encoded by the BTLA gene located on the 3rd human chromosome. BTLA is a 289 amino acid long transmembrane glycoprotein. It consists of an extracellular domain, a transmembrane domain, and a cytoplasmic domain, similar in structure to PD-1 and CTLA-4. HVEM is the main ligand of BTLA which has inhibition and activation capacities. When a T cell is fully activated HVEM is internalized, and this allows BTLA to interact in a trans manner (with molecules on other cells). This enables other cells who express HVEM to regulate activated T cells. Treg cells express HVEM and can facilitate immune suppression through interaction with BTLA. Furthermore, the blockage of BTLA together with PD-1 can help reverting the state of exhaustion.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay

Data

/ueditor/image/20240514/1715675638136578/8a4e2d516de4c2cfaae3d00ab31b44fd.png


GM-50103AB-2.png

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