Adeno-Associated Virus (AAV)

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金黄色葡萄球菌肠毒素 E

Current position：Product Center > Adeno-Associated Virus (AAV)

Adeno-Associated Virus (AAV)

Introduction

Adeno-associated virus (AAV) is currently recognized as one of the simplest single-stranded DNA defective viruses. It typically requires the assistance of adenoviruses or herpesviruses to replicate and amplify within the body.

Recombinant adeno-associated virus (rAAV) refers to a hybrid viral vector created by combining the AAV2 genome with capsid protein genes from different serotypes. In most cases, when we refer to AAV, we are actually referring to rAAV.

The rep and cap genes in the wild-type AAV genome are deleted and replaced with the promoter, gene of interest, and terminator in the recombinant AAV genome.

Genomeditech offers off-the-shelf AAV products with high titers, high transduction efficiency, diverse serotypes, and short delivery times, helping customers achieve precise, efficient, and reliable experimental results. The main product categories include optogenetics, chemogenetics, calcium indicators, Cre recombinase, and control vectors.

Advantages of AAV Vectors

1. High Safety

Wild-type AAV is a naturally defective virus, and recombinant AAV does not contain complete viral genes. So far, no evidence shows that AAV causes disease in humans. It is approved by the FDA in the U.S. as the safest viral vector for direct use in human gene therapy.

2. Low Immunogenicity

When AAV is used locally in large quantities to infect muscle, brain, eye, and other tissues, it is less likely to trigger immune responses.

3. Broad Host Range

AAV can infect both dividing and non-dividing cells.

4. Strong Tropism

There are hundreds of AAV serotypes, each with distinct tropism for different tissues or organs, making it a top choice in animal experiments.

5. Stable Expression

AAV titers can reach up to 5E+13 GC/mL, and it can maintain long-term stable expression in vivo.

6. Stable Physicochemical Properties

AAV remains inactive at 60°C and is resistant to freezing and thawing.

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Optogenetics Chemical Genetics Calcium Imaging Cre Recombinase Standard Control Vectors

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Product Center > Adeno-Associated Virus (AAV)

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Adeno-Associated Virus (AAV)

Introduction

Adeno-associated virus (AAV) is currently recognized as one of the simplest single-stranded DNA defective viruses. It typically requires the assistance of adenoviruses or herpesviruses to replicate and amplify within the body.

Recombinant adeno-associated virus (rAAV) refers to a hybrid viral vector created by combining the AAV2 genome with capsid protein genes from different serotypes. In most cases, when we refer to AAV, we are actually referring to rAAV.

The rep and cap genes in the wild-type AAV genome are deleted and replaced with the promoter, gene of interest, and terminator in the recombinant AAV genome.

Genomeditech offers off-the-shelf AAV products with high titers, high transduction efficiency, diverse serotypes, and short delivery times, helping customers achieve precise, efficient, and reliable experimental results. The main product categories include optogenetics, chemogenetics, calcium indicators, Cre recombinase, and control vectors.

Advantages of AAV Vectors

1. High Safety

Wild-type AAV is a naturally defective virus, and recombinant AAV does not contain complete viral genes. So far, no evidence shows that AAV causes disease in humans. It is approved by the FDA in the U.S. as the safest viral vector for direct use in human gene therapy.

2. Low Immunogenicity

When AAV is used locally in large quantities to infect muscle, brain, eye, and other tissues, it is less likely to trigger immune responses.

3. Broad Host Range

AAV can infect both dividing and non-dividing cells.

4. Strong Tropism

There are hundreds of AAV serotypes, each with distinct tropism for different tissues or organs, making it a top choice in animal experiments.

5. Stable Expression

AAV titers can reach up to 5E+13 GC/mL, and it can maintain long-term stable expression in vivo.

6. Stable Physicochemical Properties

AAV remains inactive at 60°C and is resistant to freezing and thawing.

Catologe

Get A Quote

Optogenetics Chemical Genetics Calcium Imaging Cre Recombinase Standard Control Vectors

Message Consultation

If you have more questions, please fill in the relevant information，we'll respond as soon as possible to assist you!

Reset

Submit

You can also contact us on the Scientist and Science Exchange marketplaces.

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