Cat.No：GM-78220AB
Product ：Anti-DXD Mouse IgG1 Antibody (4A5A12)
Cat.No：GM-78220AB
Product ：Anti-DXD Mouse IgG1 Antibody (4A5A12)
GM-78220AB-100 100μg
GM-78220AB-1000 1mg
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity >95% as determined by SDS-PAGE
Endotoxin <1 EU/mg by LAL
Sterility 0.2 μm Filtered
Target DXD (Exatecan derivative for ADC)
Clone 4A5A12
Alternative Names /
Source/lsotype Monoclonal Mouse IgG1, κ
Application ELISA, PK
Description Dxd (Exatecan derivative for ADC) is a potent inhibitor of DNA topoisomerase I (IC50: 0.31 μM), used as a conjugated drug of HER2-targeting ADC (DS-8201a). DXd is a part structure of DS-1062a which is a trophoblast cell surface protein 2 (TROP2)-targeting antibody-drug conjugate (ADC) comprised of a humanized anti-TROP2 monoclonal antibody, enzymatically cleavable peptide-linker, and DXd. DXd is an important part structure of DS-7300a, a novel B7-H3-targeting ADC, using DXd-ADC technology, which is composed of a humanized anti-B7-H3 mAb, an enzymatically cleavable tetra-peptide-based linker, and a potent TOP1 inhibitor, DXd.
Formulation Dulbecco's phosphate-buffered solution, pH 7.4.
Storage temp. Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Cat.No：GM-78220AB
Product ：Anti-DXD Mouse IgG1 Antibody (4A5A12)
GM-78220AB-100 100μg
GM-78220AB-1000 1mg
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity >95% as determined by SDS-PAGE
Endotoxin <1 EU/mg by LAL
Sterility 0.2 μm Filtered
Target DXD (Exatecan derivative for ADC)
Clone 4A5A12
Alternative Names /
Source/lsotype Monoclonal Mouse IgG1, κ
Application ELISA, PK
Description Dxd (Exatecan derivative for ADC) is a potent inhibitor of DNA topoisomerase I (IC50: 0.31 μM), used as a conjugated drug of HER2-targeting ADC (DS-8201a). DXd is a part structure of DS-1062a which is a trophoblast cell surface protein 2 (TROP2)-targeting antibody-drug conjugate (ADC) comprised of a humanized anti-TROP2 monoclonal antibody, enzymatically cleavable peptide-linker, and DXd. DXd is an important part structure of DS-7300a, a novel B7-H3-targeting ADC, using DXd-ADC technology, which is composed of a humanized anti-B7-H3 mAb, an enzymatically cleavable tetra-peptide-based linker, and a potent TOP1 inhibitor, DXd.
Formulation Dulbecco's phosphate-buffered solution, pH 7.4.
Storage temp. Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
