| Species Reactivity | Human; |
| Clone | NGM-120 |
| Source/Isotype | Monoclonal human IgG1, κ |
| Application | Bioactivity-ELISA；FACS |
| Specificity | Detects GFRAL |
| Gene | GFRAL |
| Other Names | C6orf144, GRAL, UNQ9356, bA360D14.1 |
| Gene ID | 389400 (human); |
| Background | GFRAL (GDNF Family Receptor Alpha Like) encodes a receptor protein associated with the GDNF (Glial Cell Line-Derived Neurotrophic Factor) family. NGM120 is a monoclonal antibody developed by the biopharmaceutical company NGM Biopharmaceuticals, specifically targeting the GFRAL-GDF15 signaling pathway. It works by blocking the binding of GDF15 to its receptor GFRAL, thereby inhibiting the activation of this signaling pathway. The development of NGM120 is primarily aimed at addressing cancer cachexia and certain metabolic diseases, while also exploring its potential role in cancer treatment. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Phosphate-buffered solution, pH 7.2. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
| Species Reactivity | Human; |
| Clone | NGM-120 |
| Source/Isotype | Monoclonal human IgG1, κ |
| Application | Bioactivity-ELISA；FACS |
| Specificity | Detects GFRAL |
| Gene | GFRAL |
| Other Names | C6orf144, GRAL, UNQ9356, bA360D14.1 |
| Gene ID | 389400 (human); |
| Background | GFRAL (GDNF Family Receptor Alpha Like) encodes a receptor protein associated with the GDNF (Glial Cell Line-Derived Neurotrophic Factor) family. NGM120 is a monoclonal antibody developed by the biopharmaceutical company NGM Biopharmaceuticals, specifically targeting the GFRAL-GDF15 signaling pathway. It works by blocking the binding of GDF15 to its receptor GFRAL, thereby inhibiting the activation of this signaling pathway. The development of NGM120 is primarily aimed at addressing cancer cachexia and certain metabolic diseases, while also exploring its potential role in cancer treatment. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Phosphate-buffered solution, pH 7.2. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
