Cat.No：GM-49155AB
Product：Anti-H_EGFR hIgG1 Antibody(Necitumumab)
Cat.No：GM-49155AB
Product：Anti-H_EGFR hIgG1 Antibody(Necitumumab)
GM-49155AB-10 10 μg
GM-49155AB-100 100 μg
GM-49155AB-1000 1mg
Species Reactivity Human
Clone Necitumumab
Source/Isotype Monoclonal human IgG1,κ
Application Flow cytometry; ADCC
Specificity Detects EGFR
Gene EGFR
Other Names ERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA
Gene ID 1956(human)
Background The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). In many cancer types, mutations affecting EGFR expression or activity could result in cancer. Deficient signaling of the EGFR and other receptor tyrosine kinases in humans is associated with diseases such as Alzheimer's, while over-expression is associated with the development of a wide variety of tumors. Interruption of EGFR signalling, either by blocking EGFR binding sites on the extracellular domain of the receptor or by inhibiting intracellular tyrosine kinase activity, can prevent the growth of EGFR-expressing tumours and improve the patient's condition.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Cat.No：GM-49155AB
Product：Anti-H_EGFR hIgG1 Antibody(Necitumumab)
GM-49155AB-10 10 μg
GM-49155AB-100 100 μg
GM-49155AB-1000 1mg
Species Reactivity Human
Clone Necitumumab
Source/Isotype Monoclonal human IgG1,κ
Application Flow cytometry; ADCC
Specificity Detects EGFR
Gene EGFR
Other Names ERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA
Gene ID 1956(human)
Background The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). In many cancer types, mutations affecting EGFR expression or activity could result in cancer. Deficient signaling of the EGFR and other receptor tyrosine kinases in humans is associated with diseases such as Alzheimer's, while over-expression is associated with the development of a wide variety of tumors. Interruption of EGFR signalling, either by blocking EGFR binding sites on the extracellular domain of the receptor or by inhibiting intracellular tyrosine kinase activity, can prevent the growth of EGFR-expressing tumours and improve the patient's condition.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
