Cat.No：GM-49298AB
Product：Anti-αv hIgG2 Antibody(Abituzumab)
Cat.No：GM-49298AB
Product：Anti-αv hIgG2 Antibody(Abituzumab)
GM-49298AB-10 10 μg
GM-49298AB-100 100 μg
GM-49298AB-1000 1mg
Species Reactivity Human
Clone Abituzumab
Source/Isotype Monoclonal Human IgG1/κ
Application Flow Cytometry
Specificity Detects ITGAV
Gene ITGAV
Other Names CD51, MSK8, VNRA, VTNR, ITGAV
Gene ID 3685(human)
Background ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer, and prostate cancer.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Cat.No：GM-49298AB
Product：Anti-αv hIgG2 Antibody(Abituzumab)
GM-49298AB-10 10 μg
GM-49298AB-100 100 μg
GM-49298AB-1000 1mg
Species Reactivity Human
Clone Abituzumab
Source/Isotype Monoclonal Human IgG1/κ
Application Flow Cytometry
Specificity Detects ITGAV
Gene ITGAV
Other Names CD51, MSK8, VNRA, VTNR, ITGAV
Gene ID 3685(human)
Background ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer, and prostate cancer.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
