Cat.No：GM-37413AB
Product：Anti-H_FcRn hIgG4 Antibody(Rozanolixizumab)
Cat.No：GM-37413AB
Product：Anti-H_FcRn hIgG4 Antibody(Rozanolixizumab)
GM-37413AB-10 10 μg
GM-37413AB-100 100 μg
GM-37413AB-1000 1 mg
Species Reactivity Human
Clone Rozanolixizumab
Source/Isotype Monoclonal human IgG4, κ
Application Flow cytometry
Specificity Detects FcRn.
Gene FcRn
Other Names FCGRT, FcgammaRn, alpha-chain
Gene ID 2217(human)
Background The neonatal Fc receptor (also FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor) is a protein that in humans is encoded by the FCGRT gene. It is an IgG Fc receptor which is similar in structure to the MHC class I molecule and also associates with beta-2-microglobulin. In rodents, FcRn was originally identified as the receptor that transports maternal immunoglobulin G (IgG) from mother to neonatal offspring via mother's milk, leading to its name as the neonatal Fc receptor. In humans, FcRn is present in the placenta where it transports mother's IgG to the growing fetus. FcRn has also been shown to play a role in regulating IgG and serum albumin turnover. Neonatal Fc receptor expression is up-regulated by the proinflammatory cytokine, TNF-α, and down-regulated by IFN-γ.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Cat.No：GM-37413AB
Product：Anti-H_FcRn hIgG4 Antibody(Rozanolixizumab)
GM-37413AB-10 10 μg
GM-37413AB-100 100 μg
GM-37413AB-1000 1 mg
Species Reactivity Human
Clone Rozanolixizumab
Source/Isotype Monoclonal human IgG4, κ
Application Flow cytometry
Specificity Detects FcRn.
Gene FcRn
Other Names FCGRT, FcgammaRn, alpha-chain
Gene ID 2217(human)
Background The neonatal Fc receptor (also FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor) is a protein that in humans is encoded by the FCGRT gene. It is an IgG Fc receptor which is similar in structure to the MHC class I molecule and also associates with beta-2-microglobulin. In rodents, FcRn was originally identified as the receptor that transports maternal immunoglobulin G (IgG) from mother to neonatal offspring via mother's milk, leading to its name as the neonatal Fc receptor. In humans, FcRn is present in the placenta where it transports mother's IgG to the growing fetus. FcRn has also been shown to play a role in regulating IgG and serum albumin turnover. Neonatal Fc receptor expression is up-regulated by the proinflammatory cytokine, TNF-α, and down-regulated by IFN-γ.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
