Cat. No：GM-24024AB
Product：Anti-H_CD70 hIgG1 Antibody(Cusatuzumab)
Cat. No：GM-24024AB
Product：Anti-H_CD70 hIgG1 Antibody(Cusatuzumab)
GM-24024AB-10 10 μg
GM-24024AB-100 100 μg
GM-24024AB-1000 1mg
Species Reactivity Human
Specificity Detects human CD70.
Source/Isotype Monoclonal human IgG1, λ
Other Names CD27-L, CD27L, CD27LG, LPFS3, TNFSF7, TNLG8A
Gene ID 970(human)
Application Flow cytometry: 1 μg-4 μg /test; FC-Quality tested
Background CD70 (Cluster of Differentiation 70) is a protein that in humans is encoded by CD70 gene. CD70 is also known as a ligand for CD27. In physiological condition the expression of CD70 on immune cells is transient and tightly controlled. It is primarily expressed on highly activated T cells and B cells, as well as on NK cells and mature dendritic cells. CD70 expression on T and B cells is stimulated through triggering of T and B cell receptors and can be upregulated by cytokines such as IL-1α, IL-2, IL-12, GM-CSF and TNF-α, while IL-4 and IL-10 can decrease CD70 expression. Expression of CD70 on mDCs and pDCs is induced with Toll-like receptor (TLR) triggering and CD40 ligation. Also, CD70 can be induced on NK cells upon stimulation with IL-15.
Storage Store at +4℃ short term (1-2 weeks). Store at -20℃ long term
Formulation Phosphate-buffered solution, pH 7.2.
Cat. No：GM-24024AB
Product：Anti-H_CD70 hIgG1 Antibody(Cusatuzumab)
GM-24024AB-10 10 μg
GM-24024AB-100 100 μg
GM-24024AB-1000 1mg
Species Reactivity Human
Specificity Detects human CD70.
Source/Isotype Monoclonal human IgG1, λ
Other Names CD27-L, CD27L, CD27LG, LPFS3, TNFSF7, TNLG8A
Gene ID 970(human)
Application Flow cytometry: 1 μg-4 μg /test; FC-Quality tested
Background CD70 (Cluster of Differentiation 70) is a protein that in humans is encoded by CD70 gene. CD70 is also known as a ligand for CD27. In physiological condition the expression of CD70 on immune cells is transient and tightly controlled. It is primarily expressed on highly activated T cells and B cells, as well as on NK cells and mature dendritic cells. CD70 expression on T and B cells is stimulated through triggering of T and B cell receptors and can be upregulated by cytokines such as IL-1α, IL-2, IL-12, GM-CSF and TNF-α, while IL-4 and IL-10 can decrease CD70 expression. Expression of CD70 on mDCs and pDCs is induced with Toll-like receptor (TLR) triggering and CD40 ligation. Also, CD70 can be induced on NK cells upon stimulation with IL-15.
Storage Store at +4℃ short term (1-2 weeks). Store at -20℃ long term
Formulation Phosphate-buffered solution, pH 7.2.
