Cat. No：GM-31561AB
Product：Anti-H_CD22 hIgG1 Antibody(Pinatuzumab)
Cat. No：GM-31561AB
Product：Anti-H_CD22 hIgG1 Antibody(Pinatuzumab)
GM-31561AB-10 10 μg
GM-31561AB-100 100 μg
GM-31561AB-1000 1mg
Species Reactivity Human
Clone Pinatuzumab
Source/Isotype Monoclonal human IgG1/κ
Application Flow Cytometry
Specificity Detects CD22
Gene CD22
Other Names SIGLEC-2, SIGLEC2
Gene ID 933(human)
Background CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases. CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice. In mice, it has been shown that CD22 blockade restores homeostatic microglial phagocytosis in aging brains.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Cat. No：GM-31561AB
Product：Anti-H_CD22 hIgG1 Antibody(Pinatuzumab)
GM-31561AB-10 10 μg
GM-31561AB-100 100 μg
GM-31561AB-1000 1mg
Species Reactivity Human
Clone Pinatuzumab
Source/Isotype Monoclonal human IgG1/κ
Application Flow Cytometry
Specificity Detects CD22
Gene CD22
Other Names SIGLEC-2, SIGLEC2
Gene ID 933(human)
Background CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases. CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice. In mice, it has been shown that CD22 blockade restores homeostatic microglial phagocytosis in aging brains.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
