Cat.No：GM-28860AB
Product：Anti-H_GUCY2C hIgG1 Antibody(Indusatumab)
Cat.No：GM-28860AB
Product：Anti-H_GUCY2C hIgG1 Antibody(Indusatumab)
GM-28860AB-10 10 μg
GM-28860AB-100 100 μg
GM-28860AB-1000 1mg
Species Reactivity Human
Clone Indusatumab
Source/Isotype Monoclonal Human IgG1, κ
Application Flow Cytometry
Specificity Detects GUCY2C
Gene GUCY2C
Other Names DIAR6, GC-C, GUC2C, MECIL, MUCIL, STAR
Gene ID 2984(human)
Background Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the GUCY2C gene. Guanylyl cyclase is an enzyme found in the luminal aspect of intestinal epithelium and dopamine neurons in the brain.The receptor has an extracellular ligand-binding domain, a single transmembrane region, a region with sequence similar to that of protein kinases, and a C-terminal guanylate cyclase domain. Tyrosine kinase activity mediates the GC-C signaling pathway within the cell. GUCY2C is a key receptor for heat-stable enterotoxins that are responsible for acute secretory diarrhea. Heat-stable enterotoxins are produced by pathogens such as Escherichia coli. Knockout mice deficient in the GUCY2C gene do not show secretory diarrhea on infection with E. coli, though they do with cholera toxin. This demonstrates the specificity of the GUCY2C receptor.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Cat.No：GM-28860AB
Product：Anti-H_GUCY2C hIgG1 Antibody(Indusatumab)
GM-28860AB-10 10 μg
GM-28860AB-100 100 μg
GM-28860AB-1000 1mg
Species Reactivity Human
Clone Indusatumab
Source/Isotype Monoclonal Human IgG1, κ
Application Flow Cytometry
Specificity Detects GUCY2C
Gene GUCY2C
Other Names DIAR6, GC-C, GUC2C, MECIL, MUCIL, STAR
Gene ID 2984(human)
Background Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the GUCY2C gene. Guanylyl cyclase is an enzyme found in the luminal aspect of intestinal epithelium and dopamine neurons in the brain.The receptor has an extracellular ligand-binding domain, a single transmembrane region, a region with sequence similar to that of protein kinases, and a C-terminal guanylate cyclase domain. Tyrosine kinase activity mediates the GC-C signaling pathway within the cell. GUCY2C is a key receptor for heat-stable enterotoxins that are responsible for acute secretory diarrhea. Heat-stable enterotoxins are produced by pathogens such as Escherichia coli. Knockout mice deficient in the GUCY2C gene do not show secretory diarrhea on infection with E. coli, though they do with cholera toxin. This demonstrates the specificity of the GUCY2C receptor.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
