Cat. No：GM-51148AB
Product：Anti-ACVR2B hIgG1 Antibody(Bimagrumab)
Cat. No：GM-51148AB
Product：Anti-ACVR2B hIgG1 Antibody(Bimagrumab)
GM-51148AB-10 10 μg
GM-51148AB-100 100 μg
GM-51148AB-1000 1mg
Species Reactivity Human
Clone Bimagrumab
Source/Isotype Monoclonal Human IgG1/λ
Application Flow Cytometry; Block assay; ELISA
Specificity Detects ACVR2B
Gene ACVR2B
Other Names HTX4; ACTRIIB; ActR-IIB
Gene ID Q13705
Background ACVR2B is an activin type 2 receptor.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. ACVR2B binds to activin and growth differentiation factor (GDF), which in turn activates type I receptors ansd activates downstream molecules. In addition, mutations in this gene may affect protein function in left and right axis formation and cardiovascular development, as well as reduce muscle mass and bone mass.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Cat. No：GM-51148AB
Product：Anti-ACVR2B hIgG1 Antibody(Bimagrumab)
GM-51148AB-10 10 μg
GM-51148AB-100 100 μg
GM-51148AB-1000 1mg
Species Reactivity Human
Clone Bimagrumab
Source/Isotype Monoclonal Human IgG1/λ
Application Flow Cytometry; Block assay; ELISA
Specificity Detects ACVR2B
Gene ACVR2B
Other Names HTX4; ACTRIIB; ActR-IIB
Gene ID Q13705
Background ACVR2B is an activin type 2 receptor.Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. ACVR2B binds to activin and growth differentiation factor (GDF), which in turn activates type I receptors ansd activates downstream molecules. In addition, mutations in this gene may affect protein function in left and right axis formation and cardiovascular development, as well as reduce muscle mass and bone mass.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
