Cat.No：GM-27354AB
Product：Anti-FOLR1 hIgG1 Antibody(Mirvetuximab)
Cat.No：GM-27354AB
Product：Anti-FOLR1 hIgG1 Antibody(Mirvetuximab)
GM-27354AB-10 10 μg
GM-27354AB-100 100 μg
GM-27354AB-1000 1mg
Species Reactivity Human; Cynomolgus
Clone Mirvetuximab
Source/Isotype Monoclonal human IgG1, κ
Application Flow Cytometry
Specificity Detects FOLR1
Gene FOLR1
Other Names FBP, FOLR, FRalpha, NCFTD
Gene ID P15328 (human), A0A2K5UR19-1 (cynomolgus)
Background Folate receptor 1 (FOLR1), also known as folate receptor alpha and folate binding protein, is a glycosylphosphatidylinositol-linked protein, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Cat.No：GM-27354AB
Product：Anti-FOLR1 hIgG1 Antibody(Mirvetuximab)
GM-27354AB-10 10 μg
GM-27354AB-100 100 μg
GM-27354AB-1000 1mg
Species Reactivity Human; Cynomolgus
Clone Mirvetuximab
Source/Isotype Monoclonal human IgG1, κ
Application Flow Cytometry
Specificity Detects FOLR1
Gene FOLR1
Other Names FBP, FOLR, FRalpha, NCFTD
Gene ID P15328 (human), A0A2K5UR19-1 (cynomolgus)
Background Folate receptor 1 (FOLR1), also known as folate receptor alpha and folate binding protein, is a glycosylphosphatidylinositol-linked protein, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
