Cat.No：GM-46268AB
Product：Anti-IL-4R hIgG1 Antibody(12B5)
Cat.No：GM-46268AB
Product：Anti-IL-4R hIgG1 Antibody(12B5)
GM-46268AB-10 10 μg
GM-46268AB-100 100 μg
GM-46268AB-1000 1mg
Species Reactivity Human
Clone 12B5
Source/Isotype Monoclonal Human IgG1，κ
Application Flow Cytometry；Block assay
Specificity Detects IL-4R
Gene IL-4R
Other Names CD124; IL4RA; IL-4RA;
Gene ID 3566(human)
Background The interleukin 4 receptor protein (CD124; IL4RA; IL-4RA) is a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Cat.No：GM-46268AB
Product：Anti-IL-4R hIgG1 Antibody(12B5)
GM-46268AB-10 10 μg
GM-46268AB-100 100 μg
GM-46268AB-1000 1mg
Species Reactivity Human
Clone 12B5
Source/Isotype Monoclonal Human IgG1，κ
Application Flow Cytometry；Block assay
Specificity Detects IL-4R
Gene IL-4R
Other Names CD124; IL4RA; IL-4RA;
Gene ID 3566(human)
Background The interleukin 4 receptor protein (CD124; IL4RA; IL-4RA) is a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
