Cat.No：GM-87805MAB
Product：Anti-TL1A hIgG1 Reference Antibody (Tulbio)
Cat.No：GM-87805MAB
Product：Anti-TL1A hIgG1 Reference Antibody (Tulbio)
GM-87805MAB-1mg / 1 mg
GM-87805MAB-5mg / 5 mg
GM-87805MAB-25mg / 25 mg
GM-87805MAB-50mg / 50 mg
GM-87805MAB-100mg / 100mg
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity > 95% as determined by SDS-PAGE
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Sterility 0.2 μm Filtered
Target TL1A
Clone Tulisokibart
Alternative Names TL1; TL1A; VEGI; TNLG1B; VEGI192A
Source/Isotype Human IgG1（KDEL,L234A/ L235A/ G329A), Kappa
Application /
Description The protein encoded by TNFSF15 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells but is not expressed in either B or T cells. The expression of this protein is inducible by TNF-alpha and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 (death receptor 3) and TNFRSF6B (decoy receptor 3). It can activate both the NF-κB and MAPK signalling pathways and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined.
Formulation phosphate-buffered solution, pH 7.4.
Cat.No：GM-87805MAB
Product：Anti-TL1A hIgG1 Reference Antibody (Tulbio)
GM-87805MAB-1mg / 1 mg
GM-87805MAB-5mg / 5 mg
GM-87805MAB-25mg / 25 mg
GM-87805MAB-50mg / 50 mg
GM-87805MAB-100mg / 100mg
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity > 95% as determined by SDS-PAGE
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Sterility 0.2 μm Filtered
Target TL1A
Clone Tulisokibart
Alternative Names TL1; TL1A; VEGI; TNLG1B; VEGI192A
Source/Isotype Human IgG1（KDEL,L234A/ L235A/ G329A), Kappa
Application /
Description The protein encoded by TNFSF15 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells but is not expressed in either B or T cells. The expression of this protein is inducible by TNF-alpha and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 (death receptor 3) and TNFRSF6B (decoy receptor 3). It can activate both the NF-κB and MAPK signalling pathways and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined.
Formulation phosphate-buffered solution, pH 7.4.
