Cat.No：GM-88055MAB
Product ：Anti-OSMR hIgG4 Reference Antibody (Vixabio)
Cat.No：GM-88055MAB
Product ：Anti-OSMR hIgG4 Reference Antibody (Vixabio)
GM-88055MAB-1mg / 1 mg
GM-88055MAB-5mg / 5 mg
GM-88055MAB-25mg / 5 mg * 5 vials
GM-88055MAB-50mg / 50 mg
GM-88055MAB-100mg / 50 mg * 2 vials
Expression System | CHO |
Aggregation | < 5% as determined by SEC-HPLC |
Purity | > 95% as determined by SDS-PAGE |
Species Reactivity | Human |
Clone | Vixarelimab |
Source/Isotype | hIgG4 (S228P),Lamda2 |
Application | Flow Cytometry |
Specificity | Detects OSMR |
Gene | OSMR |
Other Names | IL-31R-beta, IL-31RBB, OSMRbeta, PLCA1, OSMR |
Gene ID | 9180 (human) |
Background | OSMR (Oncostatin M Receptor) , also known as LGR1 or GP130 family members, is one of the key receptors in the IL-6 family cytokine signal transduction pathway, which often participates in signal transduction with other IL-6 family receptors. OSMR often co-constitutes with Il-31ra a binary receptor complex of IL-31RA/OSMR, mediating multiple inflammatory and neuro-immune coupling-related signaling pathways. Vixarelimab is an anti-OSMR monoclonal antibody designed to block signaling between OSM and its receptors, thereby suppressing related inflammatory and itch signals. Interference with the activation of the IL-31RA/OSMR pathway and related inflammatory signals by specifically binding OSMR. Downstream may affect Jak/STAT, MAPK and other signaling pathways, reduce the release of inflammatory mediators, alleviate itching and inflammatory response. |
Storage | Store at 2-8°C short term (1-2 weeks). Store at ≤ -20°C long term.Avoid repeated freeze-thaw. |
Formulation | Phosphate-buffered solution, pH 7.2-7.4. |
Cat.No：GM-88055MAB
Product ：Anti-OSMR hIgG4 Reference Antibody (Vixabio)
GM-88055MAB-1mg / 1 mg
GM-88055MAB-5mg / 5 mg
GM-88055MAB-25mg / 5 mg * 5 vials
GM-88055MAB-50mg / 50 mg
GM-88055MAB-100mg / 50 mg * 2 vials
Expression System | CHO |
Aggregation | < 5% as determined by SEC-HPLC |
Purity | > 95% as determined by SDS-PAGE |
Species Reactivity | Human |
Clone | Vixarelimab |
Source/Isotype | hIgG4 (S228P),Lamda2 |
Application | Flow Cytometry |
Specificity | Detects OSMR |
Gene | OSMR |
Other Names | IL-31R-beta, IL-31RBB, OSMRbeta, PLCA1, OSMR |
Gene ID | 9180 (human) |
Background | OSMR (Oncostatin M Receptor) , also known as LGR1 or GP130 family members, is one of the key receptors in the IL-6 family cytokine signal transduction pathway, which often participates in signal transduction with other IL-6 family receptors. OSMR often co-constitutes with Il-31ra a binary receptor complex of IL-31RA/OSMR, mediating multiple inflammatory and neuro-immune coupling-related signaling pathways. Vixarelimab is an anti-OSMR monoclonal antibody designed to block signaling between OSM and its receptors, thereby suppressing related inflammatory and itch signals. Interference with the activation of the IL-31RA/OSMR pathway and related inflammatory signals by specifically binding OSMR. Downstream may affect Jak/STAT, MAPK and other signaling pathways, reduce the release of inflammatory mediators, alleviate itching and inflammatory response. |
Storage | Store at 2-8°C short term (1-2 weeks). Store at ≤ -20°C long term.Avoid repeated freeze-thaw. |
Formulation | Phosphate-buffered solution, pH 7.2-7.4. |
