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Current position:Product Center > Antibodies > Biosimilar Antibodies > Anti-TNFRSF14(HVEM) hIgG4 Antibody
Anti-TNFRSF14(HVEM) hIgG4 Antibody
Product Info

Cat. No:GM-49928AB

Product:Anti-TNFRSF14(HVEM) hIgG4 Antibody



Cat. No. & Size

GM-49928AB-10           10 μg

GM-49928AB-100         100 μg

GM-49928AB-1000       1mg

Description

Species Reactivity      Human

Clone                           /

Source/Isotype           Monoclonal Human IgG4 /κ

Application                 Flow Cytometry; Activation assay

Specificity                   Detects TNFRSF14(HVEM)

Gene                            TNFSF15

Other Names              ATAR, CD270, HVEA, LIGHTR, TR2

Gene ID                       8764

Background                Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily. The HVEM–LIGHT and HVEM–BTLA-CD160 network is a self-regulating ligand/receptor system that delivers bidirectional survival, proinflammatory and inhibitory signals to T cells, NKT cells and other immune cells. Under homeostatic (non-inflammatory) conditions, HVEM and BTLA interact in cis to provide an intrinsic inhibitory signal that modulates T-cell activation. Upon activation, T cells rapidly and transiently express membrane-bound LIGHT, which binds to and internalizes HVEM. Disruption of the HVEM–BTLA complex leaves BTLA available to signal in trans through HVEM present in neighboring cells. Therefore, after T-cell activation and during the course of T-cell differentiation, the expression of HVEM decreases, while that of BTLA increases. This allows BTLA and transiently expressed LIGHT in activated T cells to interact with HVEM in trans in surrounding cells and deliver bidirectional costimulatory signals. Ligand-induced oligomerization of HVEM leads to the recruitment of TRAF2 (TNF receptor-associated factor 2) and activation of downstream nuclear factor kappa B (NF-κB) in T cells and other immune cells.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay

Data

/ueditor/image/20240524/1716519068630719/5d18344e18e3275efcd2c708078fc550.png

/ueditor/image/20240524/1716519084588316/4ffc27aa6851fa9af1cdbdf14d42e71b.png

/ueditor/image/20240524/1716519103148986/08dd552b7387b699cfd529bce703176f.png

Current position:Product Center > -- > Anti-TNFRSF14(HVEM) hIgG4 Antibody
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Anti-TNFRSF14(HVEM) hIgG4 Antibody
Product Info

Cat. No:GM-49928AB

Product:Anti-TNFRSF14(HVEM) hIgG4 Antibody



Cat. No. & Size

GM-49928AB-10           10 μg

GM-49928AB-100         100 μg

GM-49928AB-1000       1mg

Description

Species Reactivity      Human

Clone                           /

Source/Isotype           Monoclonal Human IgG4 /κ

Application                 Flow Cytometry; Activation assay

Specificity                   Detects TNFRSF14(HVEM)

Gene                            TNFSF15

Other Names              ATAR, CD270, HVEA, LIGHTR, TR2

Gene ID                       8764

Background                Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily. The HVEM–LIGHT and HVEM–BTLA-CD160 network is a self-regulating ligand/receptor system that delivers bidirectional survival, proinflammatory and inhibitory signals to T cells, NKT cells and other immune cells. Under homeostatic (non-inflammatory) conditions, HVEM and BTLA interact in cis to provide an intrinsic inhibitory signal that modulates T-cell activation. Upon activation, T cells rapidly and transiently express membrane-bound LIGHT, which binds to and internalizes HVEM. Disruption of the HVEM–BTLA complex leaves BTLA available to signal in trans through HVEM present in neighboring cells. Therefore, after T-cell activation and during the course of T-cell differentiation, the expression of HVEM decreases, while that of BTLA increases. This allows BTLA and transiently expressed LIGHT in activated T cells to interact with HVEM in trans in surrounding cells and deliver bidirectional costimulatory signals. Ligand-induced oligomerization of HVEM leads to the recruitment of TRAF2 (TNF receptor-associated factor 2) and activation of downstream nuclear factor kappa B (NF-κB) in T cells and other immune cells.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay

Data

/ueditor/image/20240524/1716519068630719/5d18344e18e3275efcd2c708078fc550.png

/ueditor/image/20240524/1716519084588316/4ffc27aa6851fa9af1cdbdf14d42e71b.png

/ueditor/image/20240524/1716519103148986/08dd552b7387b699cfd529bce703176f.png

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