Cat. No：GM-C15572
Product：H_TSLP Reporter Cell Line
Cat. No：GM-C15572
Product：H_TSLP Reporter Cell Line
Cell Growth Medium：RPMI 1640+10% FBS+ 1% P.S+8 ng/mL mouse IL-3+0.25 μg/mL Puromycin+5 μg/mL Blasticidin+50 μg/mL G418
Cell Freezing Medium：90% FBS+10% DMSO
Assay Buffer：RPMI 1640+1% FBS+1% P.S
Thymic stromal lymphopoietin (TSLP) is a protein of the cytokine family that plays a crucial role in the maturation of T cell populations by activating antigen-presenting cells. TSLP is primarily produced by non-hematopoietic cells such as fibroblasts, epithelial cells, and various types of stromal or stromal-like cells. TSLP forms a trimeric signaling complex with the thymic stromal lymphopoietin receptor CRLF2 (TSLPR) and IL-7Rα chain, which activates downstream signals.
The H_TSLP Reporter Cell Line from Genomeditech is a luciferase reporter cell line. Upon binding of TSLP to TSLPR, dimerization enhances the recruitment of IL-7Rα, forming an extracellular trimeric complex that activates downstream signals, leading to the expression of luciferase. Luciferase readings reflect the activation effect of the signaling pathway and can therefore be used for evaluating the in vitro effects of TSLP-related drugs.
| IL-4/IL-13 | ||
| IL-4 Reporter Cell Line | IL-4/IL-13 Reporter 293 Cell Line | IL-4/IL-13 Reporter 293 DDX35TM Cell Line |
| Cynomolgus_IL4R CHO-K1 Cell Line | H_IL4R CHO-K1 Cell Line | |
| Anti-IL-4R hIgG1 Antibody(12B5) | Anti-IL4R hIgG4 Antibody（Dupilumab） | Anti-IL4R hIgG4 Reference Antibody (Dupbio) |
| TSLP:TSLPR | ||
| H_TSLPR CHO-K1 Cell Line | ||
| Anti-H_TSLPR hIgG1 Antibody | Anti-TSLP hIgG2 Reference Antibody(Tezbio) | Anti-TSLP hIgG2 Antibody(Tezepelumab) |
| Cynomolgus TSLP Protein; His Tag | Human TSLP Protein; His Tag | |
| IL-5 | ||
| H_IL-5 Reporter 293 Cell Line | H_IL-5RA CHO-K1 Cell Line | H_IL-5RA HEK-293 Cell Line |
| Anti-IL5 hIgG4 Antibody(Reslizumab) | Anti-IL-5R hIgG1 Antibody(Benralizumab) | |
Cat. No：GM-C15572
Product：H_TSLP Reporter Cell Line
Cell Growth Medium：RPMI 1640+10% FBS+ 1% P.S+8 ng/mL mouse IL-3+0.25 μg/mL Puromycin+5 μg/mL Blasticidin+50 μg/mL G418
Cell Freezing Medium：90% FBS+10% DMSO
Assay Buffer：RPMI 1640+1% FBS+1% P.S
Thymic stromal lymphopoietin (TSLP) is a protein of the cytokine family that plays a crucial role in the maturation of T cell populations by activating antigen-presenting cells. TSLP is primarily produced by non-hematopoietic cells such as fibroblasts, epithelial cells, and various types of stromal or stromal-like cells. TSLP forms a trimeric signaling complex with the thymic stromal lymphopoietin receptor CRLF2 (TSLPR) and IL-7Rα chain, which activates downstream signals.
The H_TSLP Reporter Cell Line from Genomeditech is a luciferase reporter cell line. Upon binding of TSLP to TSLPR, dimerization enhances the recruitment of IL-7Rα, forming an extracellular trimeric complex that activates downstream signals, leading to the expression of luciferase. Luciferase readings reflect the activation effect of the signaling pathway and can therefore be used for evaluating the in vitro effects of TSLP-related drugs.
| IL-4/IL-13 | ||
| IL-4 Reporter Cell Line | IL-4/IL-13 Reporter 293 Cell Line | IL-4/IL-13 Reporter 293 DDX35TM Cell Line |
| Cynomolgus_IL4R CHO-K1 Cell Line | H_IL4R CHO-K1 Cell Line | |
| Anti-IL-4R hIgG1 Antibody(12B5) | Anti-IL4R hIgG4 Antibody（Dupilumab） | Anti-IL4R hIgG4 Reference Antibody (Dupbio) |
| TSLP:TSLPR | ||
| H_TSLPR CHO-K1 Cell Line | ||
| Anti-H_TSLPR hIgG1 Antibody | Anti-TSLP hIgG2 Reference Antibody(Tezbio) | Anti-TSLP hIgG2 Antibody(Tezepelumab) |
| Cynomolgus TSLP Protein; His Tag | Human TSLP Protein; His Tag | |
| IL-5 | ||
| H_IL-5 Reporter 293 Cell Line | H_IL-5RA CHO-K1 Cell Line | H_IL-5RA HEK-293 Cell Line |
| Anti-IL5 hIgG4 Antibody(Reslizumab) | Anti-IL-5R hIgG1 Antibody(Benralizumab) | |
