Cat. No：GM-84914AB
Product：Anti-H_GLP1R hIgG1 Antibody（glutazumab）
Cat. No：GM-84914AB
Product：Anti-H_GLP1R hIgG1 Antibody（glutazumab）
GM-84914AB-10 10 μg
GM-84914AB-100 100 μg
GM-84914AB-1000 1mg
Species Reactivity Human;Cynomolgus;Mouse
Clone glutazumab
Source/Isotype Monoclonal human IgG1/κ
Application Flow Cytometry
Specificity Detects GLP1R
Gene GLP1R
Other Names Glip; GLP-1; GLP-1-R; GLP-1R; GLP1R; Glpr; RATGL1RCP
Gene ID P43220 (Human ); F8V479 (cynomolgus); O35659 (Mouse)
Background GLP-1R is a receptor protein found on pancreatic cells and brain neurons. It is a member of the glucagon receptor family of G-protein-coupled receptors. GLP-1R is a pleiotropic coupled receptor, N-terminal recognition specific ligand that regulates cellular pathways by coupling to a variety of G proteins (Gαs, Gαi, GαO, and Gαq/11). After binding with GLP-1, the α subunit of G protein is dissociated from β and γ subunits, and the Gαs protein is coupled to activate adenosine cyclase (cAMP), promote the increase of cAMP content in cells and protein kinase A (PKA) content, activate the downstream signaling pathway, and cause the increase of insulin gene transcription.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Cat. No：GM-84914AB
Product：Anti-H_GLP1R hIgG1 Antibody（glutazumab）
GM-84914AB-10 10 μg
GM-84914AB-100 100 μg
GM-84914AB-1000 1mg
Species Reactivity Human;Cynomolgus;Mouse
Clone glutazumab
Source/Isotype Monoclonal human IgG1/κ
Application Flow Cytometry
Specificity Detects GLP1R
Gene GLP1R
Other Names Glip; GLP-1; GLP-1-R; GLP-1R; GLP1R; Glpr; RATGL1RCP
Gene ID P43220 (Human ); F8V479 (cynomolgus); O35659 (Mouse)
Background GLP-1R is a receptor protein found on pancreatic cells and brain neurons. It is a member of the glucagon receptor family of G-protein-coupled receptors. GLP-1R is a pleiotropic coupled receptor, N-terminal recognition specific ligand that regulates cellular pathways by coupling to a variety of G proteins (Gαs, Gαi, GαO, and Gαq/11). After binding with GLP-1, the α subunit of G protein is dissociated from β and γ subunits, and the Gαs protein is coupled to activate adenosine cyclase (cAMP), promote the increase of cAMP content in cells and protein kinase A (PKA) content, activate the downstream signaling pathway, and cause the increase of insulin gene transcription.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
