Cat.No：GM-81238AB
Product：Anti-MMAE Mouse IgG2a Antibody (8F6A3)
Cat.No：GM-81238AB
Product：Anti-MMAE Mouse IgG2a Antibody (8F6A3)
GM-81238AB-100 100μg
GM-81238AB-1000 1mg
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity >95% as determined by SDS-PAGE
Endotoxin <1 EU/mg by LAL
Sterility 0.2 μm Filtered
Target MMAE
Clone 8F6A3
Alternative Names /
Source/lsotype Monoclonal Mouse IgG2a,κ
Application ELISA, PK
Description Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. Monomethyl auristatin E is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. The linker to the monoclonal antibody is stable in extracellular fluid but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the antimitotic mechanism.
Formulation Dulbecco's phosphate-buffered solution, pH 7.4.
Storage temp. Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Cat.No：GM-81238AB
Product：Anti-MMAE Mouse IgG2a Antibody (8F6A3)
GM-81238AB-100 100μg
GM-81238AB-1000 1mg
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity >95% as determined by SDS-PAGE
Endotoxin <1 EU/mg by LAL
Sterility 0.2 μm Filtered
Target MMAE
Clone 8F6A3
Alternative Names /
Source/lsotype Monoclonal Mouse IgG2a,κ
Application ELISA, PK
Description Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. Monomethyl auristatin E is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. The linker to the monoclonal antibody is stable in extracellular fluid but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the antimitotic mechanism.
Formulation Dulbecco's phosphate-buffered solution, pH 7.4.
Storage temp. Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
