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Current position:Product Center > Antibodies > Anti-payload antibodies > Anti-ALPPL2-MMAE ADC(Dar4)[SGN-ALPV]
Anti-ALPPL2-MMAE ADC(Dar4)[SGN-ALPV]
Product info

Cat.No:GM-81151AB

Product:Anti-ALPPL2-MMAE ADC(Dar4)[SGN-ALPV]




Cat. No. & Size

GM-81151AB-100        100μg

GM-81151AB-1mg       1mg

Description️

Expression System                               CHO

Purity                                                    >95% as determined by SDS-PAGE

Aggregation                                         < 5% as determined by SEC-HPLC

Drug-to-Antibody Ratio (DAR)           4.0

Endotoxin                                            <1 EU/mg

Sterility                                                 0.22 μm Filtered

Target                                                     ALPPL2

Clone                                                      SGN-ALPV

Alternative Names                                ALPPL, ALPPL2, GCAP

Source/lsotype                                      Monoclonal Human IgG1(KDEL), κ

Application                                            Positive control of Cytotoxicity Assay

Description                                            SGN-ALPV is a novel investigational vedotin antibody–drug conjugate composed of a humanized anti-ALPP/ALPPL2 monoclonal antibody, a protease-cleavable linker, and the microtubule disrupting agent monomethyl auristatin E (MMAE). The proposed mechanism of action of SGN-ALPV is binding to ALPP/ALPPL2 on the cell surface, where it is internalized and trafficked to the lysosome. Lysosomal proteases cleave the linker to release MMAE into the cytoplasm, where it binds and disrupts the microtubule network, causing cell cycle arrest and apoptosis.

Formulation                                          20 mM Histidine, pH 6.0

Storage temp.                                       Store at +4°C short term. Store at -80°C for 36 months, avoiding freeze/thaw cycles.

Data

GM-81151AB-1.png


/ueditor/image/20240516/1715845712410745/d28c9518c18c2fd89e033f1db30a365d.png



/ueditor/image/20240516/1715845730143280/04c99bfc5bb83a5daa9352648d8b1ad5.png

Current position:Product Center > -- > Anti-ALPPL2-MMAE ADC(Dar4)[SGN-ALPV]
classify
Anti-ALPPL2-MMAE ADC(Dar4)[SGN-ALPV]
Product info

Cat.No:GM-81151AB

Product:Anti-ALPPL2-MMAE ADC(Dar4)[SGN-ALPV]




Cat. No. & Size

GM-81151AB-100        100μg

GM-81151AB-1mg       1mg

Description️

Expression System                               CHO

Purity                                                    >95% as determined by SDS-PAGE

Aggregation                                         < 5% as determined by SEC-HPLC

Drug-to-Antibody Ratio (DAR)           4.0

Endotoxin                                            <1 EU/mg

Sterility                                                 0.22 μm Filtered

Target                                                     ALPPL2

Clone                                                      SGN-ALPV

Alternative Names                                ALPPL, ALPPL2, GCAP

Source/lsotype                                      Monoclonal Human IgG1(KDEL), κ

Application                                            Positive control of Cytotoxicity Assay

Description                                            SGN-ALPV is a novel investigational vedotin antibody–drug conjugate composed of a humanized anti-ALPP/ALPPL2 monoclonal antibody, a protease-cleavable linker, and the microtubule disrupting agent monomethyl auristatin E (MMAE). The proposed mechanism of action of SGN-ALPV is binding to ALPP/ALPPL2 on the cell surface, where it is internalized and trafficked to the lysosome. Lysosomal proteases cleave the linker to release MMAE into the cytoplasm, where it binds and disrupts the microtubule network, causing cell cycle arrest and apoptosis.

Formulation                                          20 mM Histidine, pH 6.0

Storage temp.                                       Store at +4°C short term. Store at -80°C for 36 months, avoiding freeze/thaw cycles.

Data

GM-81151AB-1.png


/ueditor/image/20240516/1715845712410745/d28c9518c18c2fd89e033f1db30a365d.png



/ueditor/image/20240516/1715845730143280/04c99bfc5bb83a5daa9352648d8b1ad5.png

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