Cat.No：GM-49468AB
Product：Anti-H_HER2 hIgG1 Antibody(Margetuximab)
Cat.No：GM-49468AB
Product：Anti-H_HER2 hIgG1 Antibody(Margetuximab)
GM-49468AB-10 10 μg
GM-49468AB-100 100 μg
GM-49468AB-1000 1mg
Species Reactivity Human; Cynomolgus
Clone Margetuximab
Source/Isotype Monoclonal Human IgG1/κ
Application Flow Cytometry
Specificity Detects HER2
Gene HER2
Other Names CD340, HER-2, HER-2/neu, ERBB2, MLN 19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2
Gene ID 2064(human); 102146608(Cynomolgus)
Background Human epidermal growth factor 2 is also known as erbB-2 and Neu; it is a member of the ErbBs or type I receptor tyrosine kinase family, which also includes the epidermal growth factor receptor 1 (EGFR or HER1), erbB-3 (HER3), and erbB-4 (HER4). Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers. Binding of the c-Cbl ubiquitin ligase to ErbB2 at Tyr1112 leads to ErbB2 poly-ubiquitination and enhances degradation of this kinase. ErbB2 is a key therapeutic target in the treatment of breast cancer and other carcinomas and targeting the regulation of ErbB2 degradation by the c-Cbl-regulated proteolytic pathway is one potential therapeutic strategy.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Cat.No：GM-49468AB
Product：Anti-H_HER2 hIgG1 Antibody(Margetuximab)
GM-49468AB-10 10 μg
GM-49468AB-100 100 μg
GM-49468AB-1000 1mg
Species Reactivity Human; Cynomolgus
Clone Margetuximab
Source/Isotype Monoclonal Human IgG1/κ
Application Flow Cytometry
Specificity Detects HER2
Gene HER2
Other Names CD340, HER-2, HER-2/neu, ERBB2, MLN 19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2
Gene ID 2064(human); 102146608(Cynomolgus)
Background Human epidermal growth factor 2 is also known as erbB-2 and Neu; it is a member of the ErbBs or type I receptor tyrosine kinase family, which also includes the epidermal growth factor receptor 1 (EGFR or HER1), erbB-3 (HER3), and erbB-4 (HER4). Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers. Binding of the c-Cbl ubiquitin ligase to ErbB2 at Tyr1112 leads to ErbB2 poly-ubiquitination and enhances degradation of this kinase. ErbB2 is a key therapeutic target in the treatment of breast cancer and other carcinomas and targeting the regulation of ErbB2 degradation by the c-Cbl-regulated proteolytic pathway is one potential therapeutic strategy.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
