Cat.No：GM-81146AB
Product：Anti-HER2-DM1 ADC(Dar4)[Trastuzumab emtansine,T-DM1]
Cat.No：GM-81146AB
Product：Anti-HER2-DM1 ADC(Dar4)[Trastuzumab emtansine,T-DM1]
GM-81146AB-1mg 1mg
GM-81146AB-5mg 5mg
GM-81146AB-25mg 25mg
GM-81146AB-50mg 50mg
GM-81146AB-100mg 100mg
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity >95% as determined by SDS-PAGE
Drug-to-Antibody Ratio (DAR) 4
Endotoxin <1 EU/mg, determined by LAL gel clotting assay
Sterility 0.22 μm Filtered
Target HER2
Clone Trastuzumab emtansine,T-DM1
Alternative Names CD340, HER-2, HER-2/neu, ERBB2, MLN 19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2
Source / Isotype Human IgG1 (KEEM),Kappa
Application Negative control
Description Human epidermal growth factor 2 is also known as erbB-2 and Neu; it is a member of the ErbBs or type I receptor tyrosine kinase family, which also includes the epidermal growth factor receptor 1 (EGFR or HER1), erbB-3 (HER3), and erbB-4 (HER4). Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers. Binding of the c-Cbl ubiquitin ligase to ErbB2 at Tyr1112 leads to ErbB2 poly-ubiquitination and enhances degradation of this kinase. ErbB2 is a key therapeutic target in the treatment of breast cancer and other carcinomas and targeting the regulation of ErbB2 degradation by the c-Cbl-regulated proteolytic pathway is one potential therapeutic strategy.
Formulation Dulbecco's phosphate-buffered saline, pH 7.4
Storage temp. Store at +4°C short term. Store at -20°C or -80°C long term, avoiding freeze/thaw cycles.
Cat.No：GM-81146AB
Product：Anti-HER2-DM1 ADC(Dar4)[Trastuzumab emtansine,T-DM1]
GM-81146AB-1mg 1mg
GM-81146AB-5mg 5mg
GM-81146AB-25mg 25mg
GM-81146AB-50mg 50mg
GM-81146AB-100mg 100mg
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity >95% as determined by SDS-PAGE
Drug-to-Antibody Ratio (DAR) 4
Endotoxin <1 EU/mg, determined by LAL gel clotting assay
Sterility 0.22 μm Filtered
Target HER2
Clone Trastuzumab emtansine,T-DM1
Alternative Names CD340, HER-2, HER-2/neu, ERBB2, MLN 19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2
Source / Isotype Human IgG1 (KEEM),Kappa
Application Negative control
Description Human epidermal growth factor 2 is also known as erbB-2 and Neu; it is a member of the ErbBs or type I receptor tyrosine kinase family, which also includes the epidermal growth factor receptor 1 (EGFR or HER1), erbB-3 (HER3), and erbB-4 (HER4). Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers. Binding of the c-Cbl ubiquitin ligase to ErbB2 at Tyr1112 leads to ErbB2 poly-ubiquitination and enhances degradation of this kinase. ErbB2 is a key therapeutic target in the treatment of breast cancer and other carcinomas and targeting the regulation of ErbB2 degradation by the c-Cbl-regulated proteolytic pathway is one potential therapeutic strategy.
Formulation Dulbecco's phosphate-buffered saline, pH 7.4
Storage temp. Store at +4°C short term. Store at -20°C or -80°C long term, avoiding freeze/thaw cycles.
