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Current position:Product Center > Antibodies > Biosimilar Antibodies > Anti-PD-1 hIgG4 Reference Antibody (Tislbio)
Anti-PD-1 hIgG4 Reference Antibody (Tislbio)
Product Info

Cat. No:GM-86861MAB

Product:Anti-PD-1 hIgG4 Reference Antibody (Tislbio)


Cat. No. & Size

GM-86861MAB-1mg / 1 mg

GM-86861MAB-5mg / 5 mg

GM-86861MAB-25mg / 25 mg

GM-86861MAB-50mg / 50 mg

GM-86861MAB-100mg / 100 mg


Description

Expression System          CHO

Aggregation                      < 5% as determined by SEC-HPLC

Purity                                > 95% as determined by SDS-PAGE

Endotoxin                        < 1 EU/mg, determined by LAL gel clotting assay

Sterility                             0.2 μm Filtered

Target                               PD-1

Clone                               Tislelizumab

Alternative Names           CD279, PD-1, PDCD1, SLEB2, hPD-1, hPD-l, hSLE1

Source/Isotype                Human IgG4(S228P,E233P/F234V,L235A/D265A),Kappa

Application                       /

Description                       The programmed cell death 1 protein (PD-1, PDCD1, CD279) is a member of the CD28 family of immunoreceptors that regulate T cell activation and immune responses. The PD-1 protein contains an extracellular Ig V domain, a transmembrane domain, and a cytoplasmic tail that includes an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM). PD-1 is activated by the cell surface ligands PD-L1 and PD-L2. Upon activation, PD-1 ITIM and ITSM phosphorylation leads to the recruitment of the protein tyrosine phosphatases SHP-1 and SHP-2, which suppress TCR signaling. In addition to activated T-cells, PD-1 is expressed in activated B-cells and monocytes, although its function in these cell types has not been fully characterized. The PD-1 pathway plays an important role in immune tolerance; however, research studies show that cancer cells often adopt this pathway to escape immune surveillance. Consequently, blockade of PD-1 and its ligands is proving to be a sound strategy for neoplastic intervention.

Formulation                      phosphate-buffered solution, pH 7.4.

Data

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Current position:Product Center > -- > Anti-PD-1 hIgG4 Reference Antibody (Tislbio)
classify
Anti-PD-1 hIgG4 Reference Antibody (Tislbio)
Product Info

Cat. No:GM-86861MAB

Product:Anti-PD-1 hIgG4 Reference Antibody (Tislbio)


Cat. No. & Size

GM-86861MAB-1mg / 1 mg

GM-86861MAB-5mg / 5 mg

GM-86861MAB-25mg / 25 mg

GM-86861MAB-50mg / 50 mg

GM-86861MAB-100mg / 100 mg


Description

Expression System          CHO

Aggregation                      < 5% as determined by SEC-HPLC

Purity                                > 95% as determined by SDS-PAGE

Endotoxin                        < 1 EU/mg, determined by LAL gel clotting assay

Sterility                             0.2 μm Filtered

Target                               PD-1

Clone                               Tislelizumab

Alternative Names           CD279, PD-1, PDCD1, SLEB2, hPD-1, hPD-l, hSLE1

Source/Isotype                Human IgG4(S228P,E233P/F234V,L235A/D265A),Kappa

Application                       /

Description                       The programmed cell death 1 protein (PD-1, PDCD1, CD279) is a member of the CD28 family of immunoreceptors that regulate T cell activation and immune responses. The PD-1 protein contains an extracellular Ig V domain, a transmembrane domain, and a cytoplasmic tail that includes an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM). PD-1 is activated by the cell surface ligands PD-L1 and PD-L2. Upon activation, PD-1 ITIM and ITSM phosphorylation leads to the recruitment of the protein tyrosine phosphatases SHP-1 and SHP-2, which suppress TCR signaling. In addition to activated T-cells, PD-1 is expressed in activated B-cells and monocytes, although its function in these cell types has not been fully characterized. The PD-1 pathway plays an important role in immune tolerance; however, research studies show that cancer cells often adopt this pathway to escape immune surveillance. Consequently, blockade of PD-1 and its ligands is proving to be a sound strategy for neoplastic intervention.

Formulation                      phosphate-buffered solution, pH 7.4.

Data

image.png

image.png


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