Cat. No：GM-88068AB
Product：Anti-Mouse IL-4RA mIgG1 Antibody (REGN1103)
Cat. No：GM-88068AB
Product：Anti-Mouse IL-4RA mIgG1 Antibody (REGN1103)
GM-88068AB-10 10 μg
GM-88068AB-100 100 μg
GM-88068AB-1000 1mg
Species Reactivity | Mouse |
Clone | REGN1103 |
Source/Isotype | Monoclonal Mouse IgG1 Kappa |
Application | Bioactivity-ELISA |
Target | Detects IL-4R |
Gene | IL-4RA |
Other Names | CD124, IL-4R |
Gene ID | 16190 (Mouse) |
Background | Il-4ra (Interleukin-4 Receptor Alpha) is an important member of the Interleukin-4 Cytokine Receptor family. IL-4RA binds to the γc chain (common γ chain) to form a high-affinity receptor for IL-4, mediating IL-4 signaling; binds to IL-13R α1 to form a functional receptor for IL-13, mediating IL-13 signaling. By binding to IL-4 or Il-13, IL-4RA activates the JAK-STAT6 pathway (Janus kinase-signal transducer and activator of transcription 6) , regulates downstream gene expression, and regulates the expression of downstream genes, participate in B cell proliferation and differentiation (such as IgE class switching) , Th2 type immune response -LRB-helTer T cell type 2 response) , epithelial cell activation and other processes. IL-4RA receptor plays an important role in regulating humoral immunity (such as antibody production) and cellular immunity (such as T cell activation) , and is closely related to allergic reactions, asthma, and some autoimmune diseases. |
Storage | Store at 2-8℃ short term (1-2 weeks). Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
Formulation | Phosphate-buffered solution, pH 7.2-7.4. |
Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
Cat. No：GM-88068AB
Product：Anti-Mouse IL-4RA mIgG1 Antibody (REGN1103)
GM-88068AB-10 10 μg
GM-88068AB-100 100 μg
GM-88068AB-1000 1mg
Species Reactivity | Mouse |
Clone | REGN1103 |
Source/Isotype | Monoclonal Mouse IgG1 Kappa |
Application | Bioactivity-ELISA |
Target | Detects IL-4R |
Gene | IL-4RA |
Other Names | CD124, IL-4R |
Gene ID | 16190 (Mouse) |
Background | Il-4ra (Interleukin-4 Receptor Alpha) is an important member of the Interleukin-4 Cytokine Receptor family. IL-4RA binds to the γc chain (common γ chain) to form a high-affinity receptor for IL-4, mediating IL-4 signaling; binds to IL-13R α1 to form a functional receptor for IL-13, mediating IL-13 signaling. By binding to IL-4 or Il-13, IL-4RA activates the JAK-STAT6 pathway (Janus kinase-signal transducer and activator of transcription 6) , regulates downstream gene expression, and regulates the expression of downstream genes, participate in B cell proliferation and differentiation (such as IgE class switching) , Th2 type immune response -LRB-helTer T cell type 2 response) , epithelial cell activation and other processes. IL-4RA receptor plays an important role in regulating humoral immunity (such as antibody production) and cellular immunity (such as T cell activation) , and is closely related to allergic reactions, asthma, and some autoimmune diseases. |
Storage | Store at 2-8℃ short term (1-2 weeks). Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
Formulation | Phosphate-buffered solution, pH 7.2-7.4. |
Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
