C-type lectin-like molecule 1 (CLEC12A), also known as CLL-1, is a type II transmembrane glycoprotein that plays a crucial role as an inhibitory receptor in immune regulation. CLEC12A is overexpressed in 90%-95% of newly diagnosed or relapsed AML cases but is rarely seen in normal tissues. Therefore, CLEC12A is a potential target for AML therapy.