EGFR (Epidermal Growth Factor Receptor) is a transmembrane receptor tyrosine kinase that belongs to the ErbB receptor family (also known as the HER family). EGFR is expressed in various cell types and primarily functions by binding to its ligands, inducing receptor dimerization (homodimerization or heterodimerization), activating its tyrosine kinase activity, and initiating downstream signaling pathways. These pathways regulate multiple cellular biological processes, including proliferation, differentiation, migration, and survival. Abnormal activation of the EGFR signaling pathway is closely associated with the occurrence, progression, and drug resistance of various cancers, making EGFR a critical target for tumor-targeted therapy.
Genomeditech provides a variety of research tools related to the EGFR target, including overexpression cell lines, BAF3 cell lines, functional cell lines, proteins, and antibodies. These resources comprehensively support the in vitro activity validation of related drugs, offering strong support for researchers in evaluating and optimizing drug development, and facilitating their application and translation in tumor immunotherapy.
