Cat. No：GM-52191AB

Product：Anti-5T4 hIgG1 Antibody(825c)

GM-52191AB-10           10 μg

GM-52191AB-100         100 μg

GM-52191AB-1000       1mg

Species Reactivity      Human; Cynomolgus

Clone                           825c

Source/Isotype           Monoclonal Human IgG1 /κ

Application                 Flow Cytometry

Specificity                   Detects 5T4

Gene                            TPBG

Other Names              5T4AG, M6P1, WAIF1

Gene ID                       7162

Background                Trophoblast glycoprotein, also known as TPBG, 5T4, Wnt-Activated Inhibitory Factor 1 or WAIF1, is a human protein encoded by a TPBG gene. 5T4 is an antigen expressed in a number of carcinomas. It is an N-glycosylated transmembrane 72 kDa glycoprotein containing eight leucine-rich repeats. 5T4 is often referred to as an oncofetal antigen due to its expression in foetal trophoblast (where it was first discovered) or trophoblast glycoprotein (TPBG). 5T4 is found in tumors including the colorectal, ovarian, and gastric. Its expression is used as a prognostic aid in these cases. It has very limited expression in normal tissue but is widespread in malignant tumours throughout their development. One study found that 5T4 was present in 85% of a cohort of 72 colorectal carcinomas and in 81% of a cohort of 27 gastric carcinomas. 5T4 is also the target of the cancer vaccine TroVax which is in clinical trials for the treatment of a range of different solid tumour types.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay