Cat. No：GM-80717AB

Product：Anti-VEGFR2 hIgG1 Antibody(ramucirumab)

GM-80717AB-10           10 μg

GM-80717AB-100         100 μg

GM-80717AB-1000       1mg

Species Reactivity      Human

Clone                           Ramucirumab

Source/Isotype               Monoclonal human IgG1/κ

Application                 Bioactivity-ELISA

Specificity                   Detects VEGFR2

Gene                            VEGFR2

Other Names              CD309, FLK1, VEGFR, KDR

Gene ID                       3791 (human)

Background                TVEGFR2 (Vascular Endothelial Growth Factor Receptor 2), also known as KDR (Kinase Insert Domain Receptor) or FLK-1, is a key member of the vascular endothelial growth factor receptor family and is primarily expressed on the surface of vascular endothelial cells. As a tyrosine kinase receptor, VEGFR2 binds to its ligands (such as VEGF-A), activating its tyrosine kinase activity and initiating a series of downstream signaling cascades, including the PI3K/AKT, RAS/RAF/MEK/ERK, and PLCγ pathways. These signaling pathways play critical roles in regulating cell proliferation, migration, and survival.Ramucirumab is a monoclonal antibody targeting VEGFR2. By blocking the interaction between VEGF and VEGFR2, it inhibits angiogenesis and has been approved for the treatment of various cancers. This targeted therapeutic strategy has demonstrated significant efficacy in suppressing tumor angiogenesis, thereby preventing tumor growth and metastasis.

Storage                        Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

Formulation                Phosphate-buffered solution, pH 7.2.

Endotoxin                    < 1 EU/mg, determined by LAL gel clotting assay