Cat. No：GM-81622AB
Product：Anti-ITGB6 hIgG1 Antibody(SGN-B6A)
Cat. No：GM-81622AB
Product：Anti-ITGB6 hIgG1 Antibody(SGN-B6A)
GM-81622AB-10 10 μg
GM-81622AB-100 100 μg
GM-81622AB-1000 1mg
Species Reactivity | Human; Cynomolgus |
Clone | SGN-B6A |
Source/Isotype | human IgG1, Kappa |
Application | Flow cytometry |
Specificity | Detects ITGB6 |
Gene | ITGB6 |
Other Names | Integrin beta-6 |
Gene ID | 3694(Human); 9541(Cynomolgus); |
Background | ITGB6 is the β6 subunit of the integrin αvβ6, which is a crucial subunit controlling the expression of the entire heterodimer αvβ6. (ITGB6) is the limiting subunit for the formation of the αvβ6 integrin, as it can only bind with αv. Therefore, the expression of the αvβ6 integrin depends on the transcriptional activity of the β6 integrin gene, which is only expressed in epithelial cells. The integrin αvβ6 is exclusively expressed on epithelial cells and is expressed at low levels in most normal healthy tissues. However, it is frequently upregulated in diseases such as cancer and fibrosis, with an estimated one-third of all solid tumors showing upregulation, which is associated with disease progression and poor prognosis. Multiple studies have shown that the severity of many cancers, including lung, breast, colon, gastric, and ovarian cancer, is related to the expression of αvβ6. In summary, αvβ6 plays a regulatory role in epithelial remodeling during development, tissue repair, and tumor formation. |
Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
Formulation | Phosphate-buffered solution, pH 7.2-7.4. |
Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
Cat. No：GM-81622AB
Product：Anti-ITGB6 hIgG1 Antibody(SGN-B6A)
GM-81622AB-10 10 μg
GM-81622AB-100 100 μg
GM-81622AB-1000 1mg
Species Reactivity | Human; Cynomolgus |
Clone | SGN-B6A |
Source/Isotype | human IgG1, Kappa |
Application | Flow cytometry |
Specificity | Detects ITGB6 |
Gene | ITGB6 |
Other Names | Integrin beta-6 |
Gene ID | 3694(Human); 9541(Cynomolgus); |
Background | ITGB6 is the β6 subunit of the integrin αvβ6, which is a crucial subunit controlling the expression of the entire heterodimer αvβ6. (ITGB6) is the limiting subunit for the formation of the αvβ6 integrin, as it can only bind with αv. Therefore, the expression of the αvβ6 integrin depends on the transcriptional activity of the β6 integrin gene, which is only expressed in epithelial cells. The integrin αvβ6 is exclusively expressed on epithelial cells and is expressed at low levels in most normal healthy tissues. However, it is frequently upregulated in diseases such as cancer and fibrosis, with an estimated one-third of all solid tumors showing upregulation, which is associated with disease progression and poor prognosis. Multiple studies have shown that the severity of many cancers, including lung, breast, colon, gastric, and ovarian cancer, is related to the expression of αvβ6. In summary, αvβ6 plays a regulatory role in epithelial remodeling during development, tissue repair, and tumor formation. |
Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
Formulation | Phosphate-buffered solution, pH 7.2-7.4. |
Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
