Cat.No：GM-86372MAB
Product：Anti-H_FOLR1 hIgG1 Reference Antibody(Mirvebio)
Cat.No：GM-86372MAB
Product：Anti-H_FOLR1 hIgG1 Reference Antibody(Mirvebio)
GM-86372MAB-1mg / 1 mg
GM-86372MAB-5mg / 5 mg
GM-86372MAB-25mg / 25 mg
GM-86372MAB-50mg / 50 mg
GM-86372MAB-100mg / 100mg
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity > 95% as determined by SDS-PAGE
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Sterility 0.2 μm Filtered
Target FOLR1
Clone Mirvetuximab
Alternative Names FBP, FOLR, FRalpha, NCFTD
Source/Isotype Monoclonal Human IgG1（KDEL，delta 447K), Kappa
Application ELISA
Description Folate receptor 1 (FOLR1), also known as folate receptor alpha and folate binding protein, is a glycosylphosphatidylinositol-linked protein, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.
Formulation phosphate-buffered solution, pH 7.4.
SDS-PAGE
On SDS-PAGE under reducing (R)/non-reducing(N-R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
SEC-HPLC
The purity of this product is more than 95% verified by SEC-HPLC
Indirect ELISA
Human FOLR1 Protein; His Tag (Catalog # GM-84314RP) was immobilized at 1 μg/ml (100 μL/well). Increasing concentrations of Anti-FOLR1 hIgG1 Reference Antibody(Mirvebio) (Catalog # GM-86372MAB) were added.
Cat.No：GM-86372MAB
Product：Anti-H_FOLR1 hIgG1 Reference Antibody(Mirvebio)
GM-86372MAB-1mg / 1 mg
GM-86372MAB-5mg / 5 mg
GM-86372MAB-25mg / 25 mg
GM-86372MAB-50mg / 50 mg
GM-86372MAB-100mg / 100mg
Expression System CHO
Aggregation < 5% as determined by SEC-HPLC
Purity > 95% as determined by SDS-PAGE
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Sterility 0.2 μm Filtered
Target FOLR1
Clone Mirvetuximab
Alternative Names FBP, FOLR, FRalpha, NCFTD
Source/Isotype Monoclonal Human IgG1（KDEL，delta 447K), Kappa
Application ELISA
Description Folate receptor 1 (FOLR1), also known as folate receptor alpha and folate binding protein, is a glycosylphosphatidylinositol-linked protein, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.
Formulation phosphate-buffered solution, pH 7.4.
SDS-PAGE
On SDS-PAGE under reducing (R)/non-reducing(N-R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
SEC-HPLC
The purity of this product is more than 95% verified by SEC-HPLC
Indirect ELISA
Human FOLR1 Protein; His Tag (Catalog # GM-84314RP) was immobilized at 1 μg/ml (100 μL/well). Increasing concentrations of Anti-FOLR1 hIgG1 Reference Antibody(Mirvebio) (Catalog # GM-86372MAB) were added.
