Cat. No：GM-87353MAB

Product：Anti-IL17A hIgG1 Reference Antibody (Secubio)

GM-87353MAB-1mg / 1 mg

GM-87353MAB-5mg / 5 mg

GM-87353MAB-25mg / 25 mg

GM-87353MAB-50mg / 50mg

GM-87353MAB-100mg / 100 mg

Expression System     CHO

Aggregation               < 5% as determined by SEC-HPLC

Purity                          > 95% as determined by SDS-PAGE

Endotoxin                   < 1 EU/mg, determined by LAL gel clotting assay

Sterility                       0.2 μm Filtered

Target                            IL17A

Clone                             Secukinumab

Alternative Names   CTLA-8, CTLA8, IL-17, IL-17A, IL17, ILA17

Source/Isotype           Human IgG1(REEM), Kappa

Application                  /

Description                   This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Formulation               Phosphate-buffered solution, pH 7.4.