Cat. No：GM-87935AB
Product：Anti-H_TSHR mIgG2a Antibody(KSAb2)
Cat. No：GM-87935AB
Product：Anti-H_TSHR mIgG2a Antibody(KSAb2)
GM-87935AB-10 10 μg
GM-87935AB-100 100 μg
GM-87935AB-1000 1 mg
Species Reactivity | Human、Mouse、Cynomolgus |
Clone | KSAb2 |
Source/Isotype | Monoclonal mIgG2a/κ |
Application | Flow cytometry; Activation assay |
Specificity | Detects TSHR |
Gene | TSHR |
Other Names | CHNG1, LGR3, hTSHR-I |
Gene ID | 7253 (human) |
Background | The TSHR (Thyroid Stimulating Hormone Receptor) gene encodes a transmembrane G protein-coupled receptor essential for thyroid function regulation. Expressed on thyroid follicular cell membranes, it binds TSH to activate signaling pathways like cAMP-PKA, controlling thyroid hormone (T3 and T4) synthesis and maintaining metabolic and endocrine balance.TSHR antibodies (TSHR-Ab) are highly specific tools for studying TSHR function and thyroid disease mechanisms. In Graves' disease, stimulatory antibodies (TSAb) mimic TSH, overactivating TSHR and causing excessive hormone secretion, while blocking antibodies (TBAb) inhibit TSH binding, leading to hypothyroidism. TSHR antibodies are valuable in disease diagnosis, drug development, and animal model construction, supporting thyroid disease research and clinical applications. |
Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
Formulation | Phosphate-buffered solution, pH 7.2-7.4. |
Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
Cat. No：GM-87935AB
Product：Anti-H_TSHR mIgG2a Antibody(KSAb2)
GM-87935AB-10 10 μg
GM-87935AB-100 100 μg
GM-87935AB-1000 1 mg
Species Reactivity | Human、Mouse、Cynomolgus |
Clone | KSAb2 |
Source/Isotype | Monoclonal mIgG2a/κ |
Application | Flow cytometry; Activation assay |
Specificity | Detects TSHR |
Gene | TSHR |
Other Names | CHNG1, LGR3, hTSHR-I |
Gene ID | 7253 (human) |
Background | The TSHR (Thyroid Stimulating Hormone Receptor) gene encodes a transmembrane G protein-coupled receptor essential for thyroid function regulation. Expressed on thyroid follicular cell membranes, it binds TSH to activate signaling pathways like cAMP-PKA, controlling thyroid hormone (T3 and T4) synthesis and maintaining metabolic and endocrine balance.TSHR antibodies (TSHR-Ab) are highly specific tools for studying TSHR function and thyroid disease mechanisms. In Graves' disease, stimulatory antibodies (TSAb) mimic TSH, overactivating TSHR and causing excessive hormone secretion, while blocking antibodies (TBAb) inhibit TSH binding, leading to hypothyroidism. TSHR antibodies are valuable in disease diagnosis, drug development, and animal model construction, supporting thyroid disease research and clinical applications. |
Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
Formulation | Phosphate-buffered solution, pH 7.2-7.4. |
Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
