|
Species Reactivity |
Human, Cynomolgus |
|
Clone |
vilamakitug |
|
Source/Isotype |
Human IgG4(S228P), Kappa |
|
Application |
Flow Cytometry; Bioactivity-ELISA |
|
Target |
Detects IL1A |
|
Gene |
IL1A |
|
Other Names |
IL-1 alpha, IL-1A, IL1, IL1-ALPHA, IL1F1 |
|
Gene ID |
3552 (human); 9541 (Cynomolgus) |
|
Background |
The Interleukin-1 alpha gene, located on chromosome 2, encodes the Interleukin-1 alpha protein and belongs to MedlinePlus, a member of the IL-1 cytokine family. The IL1A gene encodes il-1α, a key molecule linking innate and adaptive immunity, which plays a central role in inflammation and tumorigenesis. Vilamakitug (XB-2001) is a human igg4κ monoclonal antibody against il-1α, which provides a new therapeutic option for il-1α-related diseases, especially in the treatment of purulent hidradenitis and pancreatic cancer. |
|
Storage |
Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
|
Formulation |
Supplied as a 0.2 μm filtered solution of PBS, pH 7.2-7.4. |
|
Endotoxin |
< 1 EU/mg, determined by LAL gel clotting assay
|
