|
Species Reactivity |
Human |
|
Clone |
1G12 |
|
Source/Isotype |
Mouse IgG1, Kappa |
|
Application |
Bioactivity-ELISA |
|
Target |
Detects IL18RA |
|
Gene |
IL18RA |
|
Other Names |
CD218a, CDw218a, IL-18R-alpha, IL-18Ralpha, IL-1Rrp, IL18R1, IL18Ralpha2, IL1RRP |
|
Gene ID |
8809 (Human) |
|
Background |
The IL18RA gene encodes interleukin-18 receptor α (IL-18R α) , which, as a member of the IL-1 receptor family, is a core regulatory node of the IL-18 signaling pathway. The protein encoded by this gene is composed of 515 amino acids, including extracellular domain, transmembrane domain and intracellular TIR domain. It activates nf-κb and MAPK signaling pathway by forming a complex with coreceptor IL-18R β, regulation of innate and adaptive immune responses. IL-18RΑ is widely expressed in synovial fibroblasts, T cells, B cells, myeloid monocytes, etc. , its abnormal activation is closely related to autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and psoriasis. |
|
Storage |
Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
|
Formulation |
Supplied as a 0.2 μm filtered solution of PBS, pH 7.2-7.4. |
|
Endotoxin |
< 1 EU/mg, determined by LAL gel clotting assay
|
