|
Species Reactivity |
Human |
|
Clone |
P20-V1 |
|
Source/Isotype |
Human IgG1(K214R, L234A, L235E ,G237A, D356E, L358M, delta447K), Kappa |
|
Application |
Bioactivity-ELISA |
|
Target |
Detects IL18RB |
|
Gene |
IL18RB |
|
Other Names |
ACPL, CD218b, CDw218b, IL-18R-beta, IL-18RAcP, IL-18Rbeta, IL-1R-7, IL-1R7, IL-1RacPL, IL18RAP |
|
Gene ID |
8807 (Human) |
|
Background |
The IL-18R β chain encoded by the IL18RB gene is a key component of the IL-18 signaling pathway that, together with IL-18R α, constitutes an active receptor complex that mediates IL-18-induced proinflammatory and immunomodulatory responses. The research background of this gene and its pathway is profound, involving innate immunity, inflammatory regulation and energy metabolism balance, and is closely related to many diseases such as autoimmune diseases, infectious diseases and cancer, is an important therapeutic target. |
|
Storage |
Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
|
Formulation |
Supplied as a 0.2 μm filtered solution of PBS, pH 7.2-7.4. |
|
Endotoxin |
< 1 EU/mg, determined by LAL gel clotting assay
|
