|
Species Reactivity |
Cynomolgus |
|
Clone |
bermekimab |
|
Source/Isotype |
Human IgG1 (K214R/D356E/L358M), Kappa |
|
Application |
Bioactivity-ELISA |
|
Target |
Detects IL1A |
|
Gene |
IL1A |
|
Other Names |
IL-1 alpha, IL-1A, IL1, IL1-ALPHA, IL1F1 |
|
Gene ID |
9541 (Cynomolgus) |
|
Background |
The IL1A gene encodes interleukin-1α (il-1α) , a key mediator of innate immunity and inflammatory responses. It is rapidly released by keratinocyte after skin damage, initiates downstream pro-inflammatory signaling pathways by binding and activating the IL-1R1/IL-1RAP receptor complex, and promotes the activation of the IL-1R1/IL-1RAP receptor, plays a central driving role in the pathogenesis of chronic inflammatory diseases such as atopic dermatitis (AD) . Bermekimab is a humanized monoclonal antibody developed to target this mechanism. Its central role is to specifically and high-affinity bind to il-1α, thereby blocking the interaction of il-1α with its receptor and inhibiting the resulting inflammatory cascade from the source. |
|
Storage |
Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
|
Formulation |
Supplied as a 0.2 μm filtered solution of PBS, pH 7.2-7.4. |
|
Endotoxin |
< 1 EU/mg, determined by LAL gel clotting assay
|
