|
Species Reactivity |
Human |
|
Clone |
Pembrolizumab |
|
Source/Isotype |
Human hIgG1, Kappa |
|
Application |
Bioactivity-ELISA |
|
Target |
Detects PD1 |
|
Gene |
PD1 |
|
Other Names |
PDCD1, PD1, CD279, SLEB2 |
|
Gene ID |
6622 (Human) |
|
Background |
PD-1 (Programmed cell death protein 1), also known as PD1 protein, is an immune regulatory receptor located on the surface of human cells. PD-1 is an immune checkpoint protein that regulates the activation and function of T cells by interacting with its ligands, PD-L1 (Programmed Cell Death Ligand 1) or PD-L2. PD-1 is primarily expressed on activated T cells and B cells, playing a role in suppressing immune responses and maintaining immune system balance. Research has shown that PD-1 protein plays an important role in the tumor microenvironment, where tumor cells can evade attacks from the immune system by binding to PD-L1. Therefore, the interaction between PD-1 and PD-L1 has become a critical target in tumor immunotherapy. Inhibiting the interaction between PD-1 and PD-L1 can restore the immune cells' ability to recognize and attack tumors, providing a new approach for tumor immunotherapy. |
|
Storage |
Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
|
Formulation |
Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
|
Endotoxin |
< 1 EU/mg, determined by LAL gel clotting assay
|
