|
Species Reactivity |
Human |
|
Clone |
AL002 |
|
Source/Isotype |
Human IgG1(KDEL),Kappa |
|
Application |
Activation assay; Flow Cytometry |
|
Target |
Detects TREM2 |
|
Gene |
TREM2 |
|
Other Names |
PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c |
|
Gene ID |
54209 (human) |
|
Background |
Trem2(Triggering Receptor Expressed on Myeloid Cells 2) gene is located on human genome 6q21.1, encoding a transmembrane Receptor protein belonging to immunoglobulin superfamily, which is mainly Expressed on the surface of Myeloid Cells such as microglia and macrophages, in particular, it plays a key role in specific organs such as brain, bone and adipose tissue. This gene binds to adaptor protein DAP12(DNAX-activating protein of 12 kDa) through transmembrane domain to form a signaling complex, which activates downstream Syk kinase and PI3K pathways, and then regulates cell phagocytosis, inflammation suppression and metabolic processes. |
|
Storage |
Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
|
Formulation |
Supplied as a 0.2 μm filtered solution of PBS, pH 7.2-7.4. |
|
Endotoxin |
< 1 EU/mg, determined by LAL gel clotting assay
|
