Species Reactivity Human
Clone sibeprenlimab
Source/Isotype Human IgG2, kappa
Application Bioactivity-ELISA
Target Detects APRIL
Gene APRIL
Other Names TNFSF13,TALL-2,TRDL-1,CD256,TALL2,ZTNF2
Gene ID 8741 (Human)
Background APRIL is a type II TNF superfamily membrane protein encoded by TNFSF13 (also TNFSF13A). It is expressed in various immune and some non-hematopoietic cells. It exists in membrane-bound and soluble forms (soluble via shedding). APRIL promotes B cell survival, maturation, differentiation, and immunoglobulin production; its dysregulation is linked to autoimmunity and certain hematologic cancers.
APRIL binds primarily to TACI and BCMA receptors, activating canonical and noncanonical NF-κB and MAPK pathways. This upregulates anti-apoptotic genes (e.g., BCL2 family) and plasma cell differentiation factors, supporting long-lasting humoral responses. APRIL can cooperate with BAFF to modulate signaling. Dysregulated APRIL–receptor signaling is associated with autoimmunity, making it a therapeutic target in diseases like SLE and monoclonal gammopathies.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
