Species Reactivity Human
Clone hzTAAB-H2L2
Source/Isotype Human IgG1 (D356E/L358M),Kappa
Application /
Specificity Detects TIE2
Gene TIE2
Other Names TIE2, Tie-2, TEK, VMCM, VMCM1, CD202b, Angiopoietin-1 receptor
Gene ID 7010 (Human)
Background Tie2 gene is located in the human genome 1p33-1p34 region, encoding tyrosine kinase receptor TIE2, is the core receptor of Angiopoietin, mainly expressed in vascular endothelium, it plays a key role in physiological and pathological angiogenesis such as embryonic vascular development, wound healing and tumor angiogenesis. Its function is regulated by the ligands Ang-1 and Ang-2: Ang-1 acts as an agonist, induces receptor phosphorylation after binding to TIE2, activates downstream signaling pathways, and activates the signaling pathway of Tie2, it enhances endothelial cell-cell junctions, reduces vascular leakage and promotes tissue homeostasis; Ang-2 often acts as a competitive antagonist under pathological conditions, weakening vascular stability, and exacerbating inflammation and exudation.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
