Species Reactivity Human
Clone CMK389
Source/Isotype Human IgG1(K214R,L234A,L235A, D356E,L358M), Kappa
Application /
Specificity Detects IL18
Gene IL18
Other Names IGIF, IL-18, IL-1g, IL1F4
Gene ID 3606 (Human)
Background Interleukin-18 (IL-18) is a pro-inflammatory cytokine that plays a pivotal role in the immune response. It is produced as an inactive precursor and activated by proteolytic processing, enabling it to promote the production of interferon-gamma (IFN-γ) and amplify Th1 immune responses. IL-18 works in concert with IL-12 to enhance natural killer (NK) cell activity and T-cell activation, contributing to defenses against intracellular pathogens. Beyond its protective roles, dysregulated IL-18 signaling has been implicated in inflammatory and autoimmune conditions, making it a target for therapeutic intervention in diseases such as rheumatoid arthritis, inflammatory bowel disease, and metabolic disorders. Owing to its broad involvement in inflammation, IL-18 is studied as both a biomarker of disease activity and a potential candidate for cytokine-modulating therapies.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.
Formulation Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
