| Species Reactivity | Human |
| Clone | Sαβγ-01 |
| Source/Isotype | Human IgG1, Kappa |
| Application | / |
| Specificity | Detects SIRP |
| Gene | SIRP |
| Other Names | BIT, CD172A, MFR, MYD-1, MYD1, P84, PTPNS1, SHPS1, SIRPA |
| Gene ID | 140885 (human) |
| Background | SIRP gene family is the core molecule of immune regulation, and its representative member, SIRP α, has become a key target for cancer immunotherapy by binding to CD47, which is highly expressed on the surface of tumor cells; However, SIRP β and SIRP γ are involved in inflammatory response and autoimmune regulation by activating immune cells or regulating T cell function, respectively, the gene family can significantly enhance the anti-cancer efficacy by relieving tumor immune escape, and it also shows important application potential in the regulation of organ transplantation rejection. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
| Species Reactivity | Human |
| Clone | Sαβγ-01 |
| Source/Isotype | Human IgG1, Kappa |
| Application | / |
| Specificity | Detects SIRP |
| Gene | SIRP |
| Other Names | BIT, CD172A, MFR, MYD-1, MYD1, P84, PTPNS1, SHPS1, SIRPA |
| Gene ID | 140885 (human) |
| Background | SIRP gene family is the core molecule of immune regulation, and its representative member, SIRP α, has become a key target for cancer immunotherapy by binding to CD47, which is highly expressed on the surface of tumor cells; However, SIRP β and SIRP γ are involved in inflammatory response and autoimmune regulation by activating immune cells or regulating T cell function, respectively, the gene family can significantly enhance the anti-cancer efficacy by relieving tumor immune escape, and it also shows important application potential in the regulation of organ transplantation rejection. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
