| Species Reactivity | Human |
| Clone | WIr2D6 |
| Source/Isotype | Human IgG1, Kappa |
| Application | / |
| Specificity | Detects WISP1 |
| Gene | WISP1 |
| Other Names | CCN4, WISP1-OT1, WISP1-UT1, WISP1c, WISP1i, WISP1tc |
| Gene ID | 8840 (Human) |
| Background | The protein encoded by the WISP1 gene belongs to the CCN family of secreted glycoproteins and is localized to the human genome 8q24.1-8q24.3, consisting of 367 amino acids, and the WISP1 gene is located on the human chromosome 8q24.3, it contains insulin-like growth factor binding domain, protein complex formation domain and other structures. This gene regulates cell proliferation, migration and metabolic processes through the Wnt signaling pathway, it plays a dual role in tissue repair, tumor progression, and organ fibrosis. It can promote fibroblast activation and accelerate wound healing, it may also induce inflammation, lipogenesis and insulin resistance by activating JNK/PI3K and other pathways. Its expression level is closely related to diabetes, tumor malignancy and fibrotic disease progression. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
| Species Reactivity | Human |
| Clone | WIr2D6 |
| Source/Isotype | Human IgG1, Kappa |
| Application | / |
| Specificity | Detects WISP1 |
| Gene | WISP1 |
| Other Names | CCN4, WISP1-OT1, WISP1-UT1, WISP1c, WISP1i, WISP1tc |
| Gene ID | 8840 (Human) |
| Background | The protein encoded by the WISP1 gene belongs to the CCN family of secreted glycoproteins and is localized to the human genome 8q24.1-8q24.3, consisting of 367 amino acids, and the WISP1 gene is located on the human chromosome 8q24.3, it contains insulin-like growth factor binding domain, protein complex formation domain and other structures. This gene regulates cell proliferation, migration and metabolic processes through the Wnt signaling pathway, it plays a dual role in tissue repair, tumor progression, and organ fibrosis. It can promote fibroblast activation and accelerate wound healing, it may also induce inflammation, lipogenesis and insulin resistance by activating JNK/PI3K and other pathways. Its expression level is closely related to diabetes, tumor malignancy and fibrotic disease progression. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
