| Alternative Names | Triggering receptor expressed on myeloid cells 2 , TREM-2 |
| Source | Mouse TREM2 Protein; His Tag (GM-88455RP) is expressed from human 293 cells (HEK-293). It contains AA Leu 19 - Ser 171 (Accession # Q99NH8-1). This protein carries a His tag at the C-terminus. |
| Purity | > 90% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 17.6 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | TREM2 protein, full name Triggering Receptor Expressed on Myeloid Cells 2, is an immune receptor that belongs to the immunoglobulin superfamily. It is encoded by the TREM2 gene and is a protein associated with the human immune system. TREM2 protein was initially discovered on dendritic cells and macrophages and later detected in various myeloid cell subsets, including microglia in the central nervous system, osteoclasts, and tissue-resident macrophages. TREM2 protein regulates the survival, proliferation, and function of myeloid cells by binding to its ligands, which include bacterial products, lipids, lipoproteins, and apoptotic cells, in partnership with the adaptor protein DAP12. Myeloid cells such as macrophages, microglia, dendritic cells, and osteoclasts are important types of immune cells with critical functions in innate immunity, phagocytosis, inflammation resolution, and tissue homeostasis, making them central members of the immune system. Research indicates that TREM2 protein plays a significant role in promoting phagocytosis, enhancing anti-inflammatory responses, modulating microglial function, and maintaining tissue integrity. Additionally, the expression of TREM2 protein is associated with neurodegenerative diseases (such as Alzheimer's disease), demyelinating disorders, bone diseases, and cancer immunity, making it a potential target for immunotherapy. |
| Alternative Names | Triggering receptor expressed on myeloid cells 2 , TREM-2 |
| Source | Mouse TREM2 Protein; His Tag (GM-88455RP) is expressed from human 293 cells (HEK-293). It contains AA Leu 19 - Ser 171 (Accession # Q99NH8-1). This protein carries a His tag at the C-terminus. |
| Purity | > 90% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 17.6 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | TREM2 protein, full name Triggering Receptor Expressed on Myeloid Cells 2, is an immune receptor that belongs to the immunoglobulin superfamily. It is encoded by the TREM2 gene and is a protein associated with the human immune system. TREM2 protein was initially discovered on dendritic cells and macrophages and later detected in various myeloid cell subsets, including microglia in the central nervous system, osteoclasts, and tissue-resident macrophages. TREM2 protein regulates the survival, proliferation, and function of myeloid cells by binding to its ligands, which include bacterial products, lipids, lipoproteins, and apoptotic cells, in partnership with the adaptor protein DAP12. Myeloid cells such as macrophages, microglia, dendritic cells, and osteoclasts are important types of immune cells with critical functions in innate immunity, phagocytosis, inflammation resolution, and tissue homeostasis, making them central members of the immune system. Research indicates that TREM2 protein plays a significant role in promoting phagocytosis, enhancing anti-inflammatory responses, modulating microglial function, and maintaining tissue integrity. Additionally, the expression of TREM2 protein is associated with neurodegenerative diseases (such as Alzheimer's disease), demyelinating disorders, bone diseases, and cancer immunity, making it a potential target for immunotherapy. |
