| Alternative Names | CD217, CDw217, IL17R, CANDF5 |
| Source | Human IL-17RA Protein; His Tag (GM-88666RP) is expressed from human 293 cells (HEK-293). It contains AA Leu 33 - Trp 320 (Accession # Q96F46-1). This protein carries a His tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 34.3 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | IL-17RA protein, full name Interleukin-17 Receptor A, is an important cell membrane receptor protein and a member of the interleukin-17 receptor family. IL-17RA protein plays a crucial role in regulating inflammatory responses, host defense against extracellular bacteria and fungi, and maintaining mucosal barrier integrity in normal physiological conditions. Abnormal expression or dysregulation of IL-17RA protein is closely associated with the occurrence and development of various inflammatory and autoimmune diseases, including psoriasis, psoriatic arthritis, ankylosing spondylitis, and inflammatory bowel disease. Currently, several IL-17RA-targeted therapeutic strategies have been developed or are under clinical investigation, including monoclonal antibodies such as brodalumab, which blocks IL-17RA-mediated signaling by preventing binding of multiple IL-17 family ligands (including IL-17A, IL-17F, IL-17C, and IL-17E). In summary, IL-17RA protein plays a critical role in the development and progression of inflammatory and autoimmune diseases, and is of great significance for understanding disease pathogenesis, selecting targeted therapeutic strategies, and evaluating patient prognosis. |
| Alternative Names | CD217, CDw217, IL17R, CANDF5 |
| Source | Human IL-17RA Protein; His Tag (GM-88666RP) is expressed from human 293 cells (HEK-293). It contains AA Leu 33 - Trp 320 (Accession # Q96F46-1). This protein carries a His tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 34.3 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | IL-17RA protein, full name Interleukin-17 Receptor A, is an important cell membrane receptor protein and a member of the interleukin-17 receptor family. IL-17RA protein plays a crucial role in regulating inflammatory responses, host defense against extracellular bacteria and fungi, and maintaining mucosal barrier integrity in normal physiological conditions. Abnormal expression or dysregulation of IL-17RA protein is closely associated with the occurrence and development of various inflammatory and autoimmune diseases, including psoriasis, psoriatic arthritis, ankylosing spondylitis, and inflammatory bowel disease. Currently, several IL-17RA-targeted therapeutic strategies have been developed or are under clinical investigation, including monoclonal antibodies such as brodalumab, which blocks IL-17RA-mediated signaling by preventing binding of multiple IL-17 family ligands (including IL-17A, IL-17F, IL-17C, and IL-17E). In summary, IL-17RA protein plays a critical role in the development and progression of inflammatory and autoimmune diseases, and is of great significance for understanding disease pathogenesis, selecting targeted therapeutic strategies, and evaluating patient prognosis. |
