Cat. No：GM-C25536
Product：H_GIPR Reporter CHO-K1 Cell Line
Cat. No：GM-C25536
Product：H_GIPR Reporter CHO-K1 Cell Line
Cell Growth Medium：F12K+10% FBS+1% P.S+4 μg/mL Puromycin+4 μg/mL Blasticidin
Cell Freezing Medium：90% FBS+10% DMSO
Assay Buffer：F12K+1% FBS+1% P.S
Gastric Inhibitory Polypeptide Receptor (GIPR) is a protein encoded by the GIPR gene in the human body, activated by gastric inhibitory polypeptide (GIP), and is a member of the G protein-coupled receptor family. GIPR is primarily present in the beta cells of the pancreas. Activation of GIPR by gastric inhibitory polypeptide leads to the activation of adenylyl cyclase through binding with the heterotrimeric Gs (αβγ) protein, increasing the levels of cAMP in the cytoplasm. The elevation of cAMP activates PKA, phosphorylating transcriptional regulatory proteins and causing their translocation to the nucleus.
The H_GIPR Reporter CHO-K1 Cell Line from Genomeditech is a reporter gene cell line constructed based on the GIPR signaling pathway. When gastric inhibitory polypeptide binds with its receptor, GIPR, it phosphorylates transcriptional regulatory proteins, thus activating the expression of Luciferase. Luciferase readings represent the activation effect of the signaling pathway and can therefore be used for in vitro evaluation of GIPR-related drugs.
Cat. No：GM-C25536
Product：H_GIPR Reporter CHO-K1 Cell Line
Cell Growth Medium：F12K+10% FBS+1% P.S+4 μg/mL Puromycin+4 μg/mL Blasticidin
Cell Freezing Medium：90% FBS+10% DMSO
Assay Buffer：F12K+1% FBS+1% P.S
Gastric Inhibitory Polypeptide Receptor (GIPR) is a protein encoded by the GIPR gene in the human body, activated by gastric inhibitory polypeptide (GIP), and is a member of the G protein-coupled receptor family. GIPR is primarily present in the beta cells of the pancreas. Activation of GIPR by gastric inhibitory polypeptide leads to the activation of adenylyl cyclase through binding with the heterotrimeric Gs (αβγ) protein, increasing the levels of cAMP in the cytoplasm. The elevation of cAMP activates PKA, phosphorylating transcriptional regulatory proteins and causing their translocation to the nucleus.
The H_GIPR Reporter CHO-K1 Cell Line from Genomeditech is a reporter gene cell line constructed based on the GIPR signaling pathway. When gastric inhibitory polypeptide binds with its receptor, GIPR, it phosphorylates transcriptional regulatory proteins, thus activating the expression of Luciferase. Luciferase readings represent the activation effect of the signaling pathway and can therefore be used for in vitro evaluation of GIPR-related drugs.
