| Cat. No: GM-C30291 Product: Mouse_TNFRSF25(DR3) Reporter Jurkat Cell Line Tumor necrosis factor-like ligand 1A (TL1A), or TNFSF15, is a cytokine primarily expressed by endothelial cells. In T cells, it functions as a co-stimulator, boosting IL-2 reactivity and pro-inflammatory cytokine secretion. TL1A is the sole ligand for death receptor 3 (DR3 or TNFRSF25), a TNF receptor family member that induces apoptosis upon T cell activation. Blocking the TL1A-DR3 interaction is a potential target for chronic immune disease therapies. Furthermore, DR3 agonistic antibodies can reduce regulatory T cell suppression and enhance CD4+ T cell activity in mouse melanoma models, indicating their potential as treatments for solid tumors. Mouse_TNFRSF25(DR3) Reporter Jurkat Cell Line is a clonal stable Jurkat cell line constructed using lentiviral technology, constitutively expressing the Mouse TNFRSF25(DR3), along with signal-dependent expression of a luciferase reporter gene. It has two application scenarios: First, by adding a DR3 agonist drug to activate the downstream signaling pathways in reporter gene cells, and measuring the fluorescence signal to determine the expression of luciferase, it can be used to screen or validate agonist drugs targeting mouse DR3. Second, by adding a TL1A antagonist antibody to block the downstream mouse DR3 signaling activated by TL1A, and measuring the fluorescence signal to determine the expression of luciferase, it can be used to screen or validate antagonist drugs targeting TL1A. |  |
