Cat.No：GM-48843AB
Product：Anti-MICA/MICB hIgG1 Antibody(36 NF G236A)
Cat.No：GM-48843AB
Product：Anti-MICA/MICB hIgG1 Antibody(36 NF G236A)
GM-48843AB-10 10 μg
GM-48843AB-100 100 μg
GM-48843AB-1000 1 mg
Species Reactivity Human
Clone MICA.36-IgG1-NF-G236A
Source/Isotype Monoclonal Human IgG1 /κ
Application Flow Cytometry
Specificity Detects MICA and MICB.
Gene MICA and MICB
Other Names MIC-A,PERB11.1; PERB11.2
Gene ID MICA: 100507436(human)；MICB: 4277(human)
Background MHC class I polypeptide–related sequence A (MICA) is a highly polymorphic cell surface glycoprotein encoded by the MICA gene located within MHC locus. MICA is related to MHC class I and it has similar domain structure; however, it is not associated with β2-microglobulin nor binds peptides as conventional MHC class I molecules do MICA rather functions as a stress-induced ligand (as a danger signal) for integral membrane protein receptor NKG2D ("natural-killer group 2, member D").
MHC class I polypeptide-related sequence B (MICB) is a protein that is encoded by the MICB gene located within MHC locus. MICB is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail. MICB is a stress-induced ligand for NKG2D receptor. The heat shock stress pathway is involved in the regulation of MICB expression as transcription of MICB is regulated by promoter heat shock element.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term.Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
Cat.No：GM-48843AB
Product：Anti-MICA/MICB hIgG1 Antibody(36 NF G236A)
GM-48843AB-10 10 μg
GM-48843AB-100 100 μg
GM-48843AB-1000 1 mg
Species Reactivity Human
Clone MICA.36-IgG1-NF-G236A
Source/Isotype Monoclonal Human IgG1 /κ
Application Flow Cytometry
Specificity Detects MICA and MICB.
Gene MICA and MICB
Other Names MIC-A,PERB11.1; PERB11.2
Gene ID MICA: 100507436(human)；MICB: 4277(human)
Background MHC class I polypeptide–related sequence A (MICA) is a highly polymorphic cell surface glycoprotein encoded by the MICA gene located within MHC locus. MICA is related to MHC class I and it has similar domain structure; however, it is not associated with β2-microglobulin nor binds peptides as conventional MHC class I molecules do MICA rather functions as a stress-induced ligand (as a danger signal) for integral membrane protein receptor NKG2D ("natural-killer group 2, member D").
MHC class I polypeptide-related sequence B (MICB) is a protein that is encoded by the MICB gene located within MHC locus. MICB is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail. MICB is a stress-induced ligand for NKG2D receptor. The heat shock stress pathway is involved in the regulation of MICB expression as transcription of MICB is regulated by promoter heat shock element.
Storage Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term.Avoid repeated freeze-thaw.
Formulation Phosphate-buffered solution, pH 7.2.
Endotoxin < 1 EU/mg, determined by LAL gel clotting assay
