Cat. No：GM-C35041
Product：H_TACI Reporter Cell Line
Cat. No：GM-C35041
Product：H_TACI Reporter Cell Line
Cell Growth Medium：RPMI 1640+10% FBS+1% P.S+3.5 μg/mL Blasticidin+0.75 μg/mL Puromycin
Cell Freezing Medium：90% FBS+10% DMSO
Assay Buffer：RPMI 1640+1% FBS+1% P.S
TACI (Transmembrane Activation and CAML Interactor) is a receptor encoded by the TNFRSF13B gene, belonging to the TNF receptor superfamily. It mainly exists on B cells and plasma cells and plays an important role in the regulation of the immune system.
TACI contains two cysteine enriched domains (CRDs) in the extracellular space, which are responsible for binding to its main ligands BAFF (B-cell Activating Factor) and APRIL (A Proliferation Inducing Ligand), enabling TACI to specifically recognize and bind to ligands, thereby initiating signal transduction. TACI signaling plays a crucial role in the survival, maturation, and antibody production of B cells.
Jiman Biological H_TACI Reporter Cell Line is a Luciferase reporter gene cell line. When BAFF binds to TACI receptors, it activates downstream signaling pathways, thereby activating the expression of luciferase. The Luciferase reading represents the activation effect of the signaling pathway, and therefore can be used for in vitro efficacy evaluation of TACI related drugs.
Cat. No：GM-C35041
Product：H_TACI Reporter Cell Line
Cell Growth Medium：RPMI 1640+10% FBS+1% P.S+3.5 μg/mL Blasticidin+0.75 μg/mL Puromycin
Cell Freezing Medium：90% FBS+10% DMSO
Assay Buffer：RPMI 1640+1% FBS+1% P.S
TACI (Transmembrane Activation and CAML Interactor) is a receptor encoded by the TNFRSF13B gene, belonging to the TNF receptor superfamily. It mainly exists on B cells and plasma cells and plays an important role in the regulation of the immune system.
TACI contains two cysteine enriched domains (CRDs) in the extracellular space, which are responsible for binding to its main ligands BAFF (B-cell Activating Factor) and APRIL (A Proliferation Inducing Ligand), enabling TACI to specifically recognize and bind to ligands, thereby initiating signal transduction. TACI signaling plays a crucial role in the survival, maturation, and antibody production of B cells.
Jiman Biological H_TACI Reporter Cell Line is a Luciferase reporter gene cell line. When BAFF binds to TACI receptors, it activates downstream signaling pathways, thereby activating the expression of luciferase. The Luciferase reading represents the activation effect of the signaling pathway, and therefore can be used for in vitro efficacy evaluation of TACI related drugs.
