Cat. No：GM-C31635
Product：H_BAFFR Reporter Cell Line
Cat. No：GM-C31635
Product：H_BAFFR Reporter Cell Line
Cell Growth Medium：RPMI 1640+10% FBS+1% P.S+3.5 μg/mL Blasticidin+0.75 μg/mL Puromycin
Cell Freezing Medium：90% FBS+10% DMSO
Assay Buffer：RPMI 1640+1% FBS+1% P.S
BAFFR (B-cell activating factor receptor), also known as BR3 (BAFF receptor 3), is a receptor located on the surface of B cells. It plays a crucial role in the survival, maturation, and differentiation of B cells. BAFFR is encoded by the TNFRSF13C gene. It belongs to the tumor necrosis factor (TNF) receptor family, which structurally includes a transmembrane region and an extracellular ligand binding region.
The main ligand of BAFFR is BAFF (B-cell activating factor, also known as BLyS-Blyocyte stimulator). BAFF mediates its action by binding to BAFFR. Abnormal BAFF-BAFFR signaling is associated with various autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Therefore, BAFFR is a potential target for the treatment of these diseases. In clinical practice, anti BAFF treatment methods such as Belimumab have been used to treat certain autoimmune diseases to slow down abnormally activated B cells.
Jiman Biological H_BAFFR Reporter Cell Line is a Luciferase reporter gene cell line. When BAFF binds to BAFFR receptors, it activates downstream signaling pathways, thereby activating the expression of luciferase. The Luciferase reading represents the activation effect of the signaling pathway, and therefore can be used for in vitro efficacy evaluation of BAFF related drugs.
Cat. No：GM-C31635
Product：H_BAFFR Reporter Cell Line
Cell Growth Medium：RPMI 1640+10% FBS+1% P.S+3.5 μg/mL Blasticidin+0.75 μg/mL Puromycin
Cell Freezing Medium：90% FBS+10% DMSO
Assay Buffer：RPMI 1640+1% FBS+1% P.S
BAFFR (B-cell activating factor receptor), also known as BR3 (BAFF receptor 3), is a receptor located on the surface of B cells. It plays a crucial role in the survival, maturation, and differentiation of B cells. BAFFR is encoded by the TNFRSF13C gene. It belongs to the tumor necrosis factor (TNF) receptor family, which structurally includes a transmembrane region and an extracellular ligand binding region.
The main ligand of BAFFR is BAFF (B-cell activating factor, also known as BLyS-Blyocyte stimulator). BAFF mediates its action by binding to BAFFR. Abnormal BAFF-BAFFR signaling is associated with various autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Therefore, BAFFR is a potential target for the treatment of these diseases. In clinical practice, anti BAFF treatment methods such as Belimumab have been used to treat certain autoimmune diseases to slow down abnormally activated B cells.
Jiman Biological H_BAFFR Reporter Cell Line is a Luciferase reporter gene cell line. When BAFF binds to BAFFR receptors, it activates downstream signaling pathways, thereby activating the expression of luciferase. The Luciferase reading represents the activation effect of the signaling pathway, and therefore can be used for in vitro efficacy evaluation of BAFF related drugs.
